Evaluation of Omeprazole Effect on Glaucoma

Shahid Beheshti University of Medical Sciences

Status and phase: Unknown; Phase 1

Conditions: Glaucoma

Treatments: Drug: Placebo; Drug: Omeprazole

Study type: Interventional

Funder types: Other

Identifiers

NCT01000220

8735

Details and patient eligibility

About

Omeprazole is a safe drug listed in OTC drug due to its safety. It acts by irreversible inhibition of K/H ATP ase pump and also Na/K ATP ase, Na/H ATP ase.Considering these actions the effect of omeprazole on decreasing intra ocular pressure is an issue of debate.In this Randomized Clinical Trial conducted in labafinejad hospital, patients with glaucoma who need to take omeprazole due to GI problem are evaluated in two groups including placebo and drug users. The effect will be finally assessed.

Full description

Omeprazole is a safe drug listed in OTC drug due to its safety. It acts by irreversible inhibition of K/H ATP ase pump and also Na/K ATP ase, Na/H ATP ase.Considering these actions the effect of omeprazole on decreasing intra ocular pressure is an issue of debate.In this Randomized Clinical Trial conducted in labafinejad hospital, patients with glaucoma who need to take omeprazole due to GI problem are evaluated in two groups including placebo and drug users. The effect will be finally assessed.

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• patients with glaucoma
• 18 to 70 years
• POAG patients, Pseudoexfoliation
• no history of other systemic disease
• no history of intraocular intervention
• no history of H2 blocker or PPI consumption during the past month consuming 2 or less topical anti-glaucoma medication
• no present immune deficiency
• no addiction habit

Exclusion Criteria:

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups, including a placebo group

Omeprazole

Active Comparator group

Treatment:

Drug: Omeprazole

placebo

Placebo Comparator group

Treatment:

Drug: Placebo