Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients

Mashhad University of Medical Sciences

Status: Completed

Conditions: Graves Disease

Treatments: Drug: Methimazole

Study type: Interventional

Funder types: Other

Identifiers

NCT01560299

Metiodine

Details and patient eligibility

About

Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.

Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.

Enrollment: 150 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-65
• graves disease(TSH<0.1 &increased FT4 & positive TSI
• one or more bartlena criteria for radio-iodine therapy
• 24 hour RAIU>25%
• euthyroidism after methimazole treatment

Exclusion criteria

• pregnancy or lactation
• moderate or severe graves ophthalmopathy
• CHF or coronary heart disease
• palpable thyroid nodule
• lithium or amiodarone or lugol or ipodate treatment
• recent imaging with contrast agent
• very large goiter(more than 150 gram)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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150 participants in 3 patient groups

group one

Active Comparator group

Description:

This group will be advised to discontinue methimazole 24-48 hour before iodine therapy

Treatment:

Drug: Methimazole

Drug: Methimazole

Drug: Methimazole

group two

Active Comparator group

Description:

methimazole stopped 48-72 hour before radioiodine therapy

Treatment:

Drug: Methimazole

Drug: Methimazole

Drug: Methimazole

group three

Active Comparator group

Treatment:

Drug: Methimazole

Drug: Methimazole

Drug: Methimazole