Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease

Vakif Gureba Training and Research Hospital

Status: Completed

Conditions: Hashimoto Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01102205

tastoshashi

Details and patient eligibility

About

Oxidative stress leads to or accompanies with numerous disease. Oxidative balance in subclinical hypothyroid or euthyroid state in Hashimoto disease are not known. Effect of levothyroxine therapy on oxidative balance are also not known in hashimoto disease.

Full description

oxidative stress markers will be measured initially(TAS,TOS,OSI,PARAOXONASE,ARYLESTERASA,PON1 PHENOTYPİNG,LİPİDPEROXİD).After 3 months therapy with levothyroxine measurements will be repeated except PON1 phenotyping.

Enrollment: 130 patients

Sex: All

Ages: 18 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age more than 18 years

Exclusion criteria

• inability to give a written consent
• other conditions and drug usage affect oxidative stress

Trial design

130 participants in 3 patient groups

healthy

euthyroid hashimoto

hypothyroid hashimoto