Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial.

University of Sao Paulo

Status: Completed

Conditions: Respiratory Failure

Treatments: Device: Automatic Tube Compensation plus CPAP; Device: Continuous Positive Airway Pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT01757093

AFL-0705

Details and patient eligibility

About

The purpose of this study is to compare the oxygen consumption and energy expenditure during the spontaneous breathing trial.

Full description

Patients is going to submit to the 2 spontaneous breathing trial ( Automatic tube compensation plus continuous positive airway pressure and continuous positive airway pressure without automatic tube compensation. The oxygen consumption and energy expenditure is going to measure during the spontaneous breathing trial by indirect calorimetry.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IMPROVEMENT OR RESOLUTION OF THE UNDERLYING CAUSE OF DISEASE
• INTUBATED PATIENTS>24h
• PaO2 GREATER THAN 60 mmHg WITH FiO2 LESS THAN 40%
• PEEP=5 cmH2O

Exclusion criteria

• CARDIOVASCULAR INSTABILITY
• FEBRILE OR HYPOTHERMIA
• CHEST DRAINAGE
• RESPIRATORY RATE/TIDAL VOLUME RATIO GREATER THAN 105
• PREGNANCY
• FAIL IN THE SPONTANEOUS BREATHING TRIAL
• LEAKS IN THE CIRCUIT
• AGITATION
• NOT ACCEPT PARTICIPATE IN THE STUDY

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Automatic tube compensation plus CPAP

Experimental group

Description:

The patients is going to undergo trials of spontaneous breathing with automatic tube compensation plus continuous positive airway pressure and later a trial with continuous positive airway pressure. During 30 minutes.

Treatment:

Device: Automatic Tube Compensation plus CPAP

Device: Continuous Positive Airway Pressure

Continuous Positive Airway Pressure

Active Comparator group

Description:

The patients is going to undergo a trial of spontaneous breathing with continuous positive airway pressure and later with automatic tube compensation plus continuous positive airway pressure, during 30 minutes each.

Treatment:

Device: Automatic Tube Compensation plus CPAP

Device: Continuous Positive Airway Pressure