Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial

Future University in Egypt

Status: Active, not recruiting

Conditions: Necrotic Pulp

Treatments: Procedure: Calcium Hydroxide + mesoporous silica nanoparticles; Procedure: mesoporous silica nanoparticles paste; Procedure: Calcium Hydroxide Intracanal medication

Study type: Interventional

Funder types: Other

Identifiers

NCT07327996

raneemICM10

Details and patient eligibility

About

This study compares how well different root canal medications reduce pain and bacteria after treatment of lower molar teeth with necrotic pulp. It tests whether adding mesoporous silica nanoparticles-antibacterial particles-to calcium hydroxide makes the treatment more effective. Forty-two adult patients will be randomly assigned to receive either calcium hydroxide alone, nanoparticles alone, or a mix of both for one week during root canal therapy. measure patients' pain levels after 6h,12h,24,48h and 72 hours from treatment and the number of bacteria before and after treatment to see which method gives the best results. The goal is to make root canal treatments more comfortable and successful for future patients.

Enrollment: 42 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

• Inclusion Criteria:

  1. Patients with an age range between 18 to 40.
  2. No sex predilection.
  3. Patients with necrotic pulp.
  4. Patients able to sign informed consent.
  5. Restorable teeth.
  6. Positive patient's acceptance for participating in the study.
  7. Type III distal and mesial canal of first mandibular molar.

• Exclusion Criteria:

  1. Pregnant females

  2. Medically compromised patients.

  3. Patients having analgesics before the treatment

  4. If antibiotics have been administrated during the past two weeks pre-operatively.

  5. Patients having bruxism or clenching

  6. Patients having sever malocclusion associated with traumatic occlusion.

  7. Teeth that have:

     1. Peri-apical radiolucency
     2. Root resorption.
     3. Pulp stones or calcifications.
     4. Previous endodontic treatment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

42 participants in 3 patient groups

The root canals will be filled with calcium hydroxide paste

Active Comparator group

Description:

using calcium hydroxide paste as intracanal medication for 1week

Treatment:

Procedure: Calcium Hydroxide Intracanal medication

The root canal will be filled with mesoporous silica nanoparticles paste.

Active Comparator group

Description:

using mesoporous silica nanoparticles paste as intracanal medication for week

Treatment:

Procedure: mesoporous silica nanoparticles paste

root canals will be filled with mesoporous silica nanoparticles with calcium hydroxide paste.

Active Comparator group

Description:

using mesoporous silica nanoparticles with calcium hydroxide paste as intracanal medication for 1week

Treatment:

Procedure: Calcium Hydroxide + mesoporous silica nanoparticles