Evaluation of Paternal, Maternal and Obstetric Factors Leading to the Hepatitis B Immunization Failure in Hong Kong

The University of Hong Kong (HKU)

Status: Completed

Conditions: Hepatitis B Infection

Study type: Observational

Funder types: Other

Identifiers

NCT02443233

UW 13-270

Details and patient eligibility

About

Globally, hepatitis B virus (HBV) infection is the most common form of chronic hepatitis. There are still a lot of uncertainties on how infants acquired HBV leading to the development of chronic HBV infection despite active and passive immunoprophylaxis. The investigators would like to carry out a prospective study to answer the following questions:

1. the paternal, maternal and obstetric factors leading to immunoprophylaxis failure
2. the prevalence of immunoprophylaxis failure in Hong Kong

Enrollment: 750 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All women age ≥ 18 years
• Maternal or paternal hepatitis B carrier

Exclusion criteria

• Couples will be excluded if female partners of paternal hepatitis B carrier were occult carrier
• Plan to deliver in other units

Trial design

750 participants in 2 patient groups

Maternal hepatitis B carrier

Paternal hepatitis B carrier