Evaluation of Pathogenesis and Diagnosis of Mycoplasma Pneumoniae Community-acquired Pneumonia (CAP) (myCAP)

University of Zurich (UZH)

Status: Completed

Conditions: Antibody-secreting Cells; Diagnosis; Childhood Pneumonia; Enzyme-linked Immunospot (ELISpot); Mycoplasma Pneumonia

Treatments: Diagnostic Test: Enzyme-linked immunospot (ELISpot) assay [Blood]

Study type: Observational

Funder types: Other

Identifiers

NCT03613636

2016-00148

Details and patient eligibility

About

To investigate the Mycoplasma pneumoniae-specific circulating antibody-secreting cell (ASC) response and Mycoplasma pneumoniae-specific interferon (INF)-γ-secreting T cell response, along with polymerase chain reaction (PCR) and serology, in a cohort of children with community-acquired pneumonia (CAP) and controls.

Enrollment: 490 patients

Sex: All

Ages: 3+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

CAP cohort:

• Children of age 3 to 18 years;
• In- and outpatients;
• Clinically diagnosed community-acquired pneumonia (CAP);

Healthy control cohort:

• Healthy asymptomatic children of age 3 to 18 years undergoing an elective surgical procedure;

Family control cohort:

• Family members of index CAP patients.

Exclusion criteria

• Hospital-acquired pneumonia;
• Immunodeficiencies;
• Chronic lung disorders.

Trial design

490 participants in 3 patient groups

CAP cohort

Description:

* Children of age 3 to 16 years; * In- and outpatients; * Clinically diagnosed community-acquired pneumonia (CAP).

Treatment:

Diagnostic Test: Enzyme-linked immunospot (ELISpot) assay [Blood]

Healthy control cohort

Description:

* Healthy asymptomatic children of age 3 to 16 years; * undergoing an elective surgical procedure.

Treatment:

Diagnostic Test: Enzyme-linked immunospot (ELISpot) assay [Blood]

Family control cohort

Description:

- Family members of index CAP patients.

Treatment:

Diagnostic Test: Enzyme-linked immunospot (ELISpot) assay [Blood]