Evaluation of Patients With Knee Osteoarthritis Receiving a Prosthesis (Chondrolike)

Lille Catholic University

Status: Completed

Conditions: Bone Marrow; Perfusion; Osteoarthritis, Knee; Magnetic Resonance Imaging

Treatments: Diagnostic Test: Evaluation of histological status; Diagnostic Test: Radiology; Diagnostic Test: Dynamic contrast-enhanced magnetic resonance imaging; Diagnostic Test: Clinical evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT03644420

RT-07

Details and patient eligibility

About

Patients with osteoarthritis of the knee undergo visible joint changes in radiology and Magnetic resonance imaging (MRI) tests, but also clinically and histologically. The area of greatest change is at the subchondral/cartilage bone junction.

Investigators will determine the association between preoperative clinical evaluation (IKDC and Womac scores), radiological classifications and histopathology.

In addition, the role of inflammation in the pathogenesis of osteoarthritis is being given major interest, and inflammation is closely linked with vascularization. It was recently demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could identify the subchondral bone marrow vascularization changes occurring in osteoarthritis in animals.

These changes appeared before cartilage lesions were visible and were correlated with osteoarthritis severity. Thus the opportunity to obtain an objective assessment of bone vascularization in non-invasive conditions in humans might help better understanding osteoarthritis pathophysiology and finding new biomarkers. Investigators hypothesized that, as in animals, DCE-MRI has the ability to identify subchondral bone marrow vascularization changes in human osteoarthritis.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with knee osteoarthritis, classified Kellgren-Lawrence 3 or 4, with asymmetric femorotibial joint space narrowing
• Patients requiring a total knee prosthesis

Exclusion criteria

• Patients with a known progressive inflammatory pathology (rheumatoid arthritis,...).
• Patients with previous surgery of the knee
• Contra-indication for magnetic resonance imaging, chronic renal failure (creatinine clearance < 30 ml/min), contrast media allergy, orthopaedic hardware around the knee. Patients in whom motion artifacts impaired image analysis will be excluded.

Trial design

22 participants in 1 patient group

Knee osteoarthritis

Description:

Patients with knee osteoarthritis, classified Kellgren-Lawrence 3 or 4, with asymmetric femorotibial joint space narrowing that will follow a surgery for a prosthetic replacement of the knee wil follow the following interventions: * Clinical evaluation * Radiographic assessment of osteoarthritis * Magnetic resonance imaging (MRI) * Histological evaluation of the surgical piece

Treatment:

Diagnostic Test: Evaluation of histological status

Diagnostic Test: Dynamic contrast-enhanced magnetic resonance imaging

Diagnostic Test: Clinical evaluation

Diagnostic Test: Radiology