Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin

Pfizer

Status: Completed

Conditions: Methicillin-Resistant Staphylococcus Aureus (MRSA); Hospital-Acquired Pneumonia

Treatments: Drug: Linezolid; Drug: Vancomycin

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01561469

A5951168

Details and patient eligibility

About

The objective of this study is to review the local management of patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia treated with vancomycin or linezolid with the goal to define if any difference exists among these antimicrobials in regard to clinical and economic outcomes.

Full description

Non-randomized, retrospective, observational study

Enrollment: 188 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients will be enrolled in the study if they fulfill the following three inclusion criteria:

1. Protocol criteria for HAP/VAP: Criteria for making a correct diagnosis of HAP will be met if the patient develops a new or progressive pulmonary infiltrate associated with at least two of the following: new or increased respiratory symptomatology (cough, sputum or tracheal secretions, shortness of breath), fever or hypothermia, leukocytosis, left shift, or leukopenia, or deterioration of pulmonary function.
2. Isolation of MRSA from a respiratory sample or blood culture within 48 hours of the diagnosis of HAP/VAP
3. Treatment of MRSA HAP/VAP with either vancomycin or linezolid with incorporation of 100 patients in the vancomycin arm and 100 patients in the linezolid arm

Exclusion criteria

Patients not meeting enrollment criteria.

Trial design

188 participants in 2 patient groups

Linezolid observational cohort

Treatment:

Drug: Linezolid

Vancomycin observational cohort

Treatment:

Drug: Vancomycin