Evaluation of Peripartum Blood Loss and Postpartum Anaemia in Macrosomia & Gemini

Goethe University

Status: Enrolling

Conditions: Bloodloss in Pregnancy

Treatments: Other: Observation of Blood loss

Study type: Observational

Funder types: Other

Identifiers

NCT06201910

2023-1405

Details and patient eligibility

About

Anaemia in pregnant women occurs at a haemoglobin (Hb) concentration <11 g/dL and treatment is essential to prevent increased maternal morbidity, fetal morbidity and mortality. Studies show a distinct risk of haemorrhage in pregnant women due to increased uterine dilatation, due to twins or macrosomic singletons. Currently, prepartum anaemia management, the influence of anaemia and the administration of foreign blood concentrates are insufficiently studied. The investigators intend to conduct a monocentric retrospective analysis of this subcohort.

Full description

Patient blood management is essentially based on three pillars, and a meta-analysis has already shown that consistent use can reduce transfusions and mortality. The WHO defines anaemia in pregnant patients as a haemoglobin (Hb) concentration <11 g/dl.

Treatment of iron deficiency anaemia is essential because data show that iron deficiency anaemia is associated with increased maternal morbidity, fetal morbidity and mortality. Studies show a separate risk of bleeding in pregnant women due to increased uterine prolapse, for example in twin pregnancies or macrosomic singletons. At present, the prepartum anaemia management of patients, the influence of anaemia and the administration of foreign blood concentrates are insufficiently studied, which the investigators intend to investigate.

Enrollment: 500 estimated patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnancy

Exclusion criteria

• pre-existing coagulation disorder

Trial design

500 participants in 3 patient groups

Controll

Description:

Pregnant women without uterine dilation due to a twin pregnancy or a macrosomic singleton

Treatment:

Other: Observation of Blood loss

Gemini

Description:

Pregnant women with uterine dilation due to a twin pregnancy

Treatment:

Other: Observation of Blood loss

Makrosome

Description:

Pregnant women with uterine dilation due to a macrosomic singleton

Treatment:

Other: Observation of Blood loss