Evaluation of Peripheral Neutrophils in Antisynthetase Syndrome (NEUTROSAS)

Central Hospital, Nancy, France

Status: Completed

Conditions: Antisynthetase Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT05691725

2022PI209

Details and patient eligibility

About

Antisynthetase syndrome (AS) is a rare overlapping myositis characterized by cellular and humoral autoimmune responses directed against aminoacyl-tRNA synthetases. A pathogenic role of neutrophils was described during inflammatory myopathies, with increased netosis correlated with disease activity and muscle damage. Higher number of alveolar neutrophils was observed in patients with rapidly progressive forms of interstitial lung disease.

Peripheral neutrophils could represent a simple biomarker of severity and activity in patients with antisynthetase syndrome.

The main objective is to compare circulating neutrophils between severe and non severe patients with antisynthetase syndrome. Secondary objectives are: 1) to evaluate correlation between circulating neutrophils and organ-specific severity, 2) to compare circulating neutrophils at time of diagnosis and circulating neutrophils after 6 months of treatment in patients with antisynthetase syndrome.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients with antisyntheatse syndrome according to Solomon criteria

Trial design

40 participants in 1 patient group

Patients with antisynthetase syndrome