Evaluation of Pesticide Exposure in the General Population (SIGEXPOSOME)

Léon Bérard Center

Status: Completed

Conditions: Pesticide Poisoning

Treatments: Biological: Questionnaire, blood, urine, hair and dust samplings

Study type: Observational

Funder types: Other

Identifiers

NCT02986763

SIGEXPOSOME

Details and patient eligibility

About

An association has been suggested with several diseases including cancer and IARC has classified several pesticides as carcinogenic, probably carcinogenic. There is a need for a better characterisation of environmental pesticides exposures and identification of suitable biomarkers of exposure and effect. A better understanding of the impact of pesticide exposure on metabolomic, transcriptomic and epigenetic changes, is essential to strengthen epidemiological hypotheses on the association with several cancer types.

The main objective of the project is to validate a GIS (geographic information system) based method to assess environmental pesticide exposures, using environmental (contamination of housedust) and biological (blood and urine samples) measures. The project aims further to investigate a potential link between housedust contamination and biological measures in healthy non-smoking male residents and explore the impact of environmental pesticide exposure on metabolomics, transcriptomic and epigenetic parameters.

Full description

The project involves a pilot phase involving repeated (twice) sampling in 20 male non-smoking volunteers living in the Beaujolais region (France) to perform appropriate calibrations for metabolomic, transcriptomic and epigenetic analyses. The main study will be conducted in a sample of 150 male non-smoking volunteers and 50 professional pesticides applicators from the same region (3 sampling periods).

Enrollment: 166 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non smokers in the last two years Living in the Beaujolais region (France) within 1000m of vignards Informed consent signed

Exclusion criteria

• Volunteers sharing the same households with professional applicators of pesticides

Trial design

166 participants in 2 patient groups

Professional pesticides

Description:

A specific questionnaire with professional information about pesticide uses is added for this arm Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling

Treatment:

Biological: Questionnaire, blood, urine, hair and dust samplings

Volunteers

Description:

Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling

Treatment:

Biological: Questionnaire, blood, urine, hair and dust samplings