Evaluation of Pharmacogenetic Factors Affecting Fentanyl Requirements for Postoperative Pain Control

I

Inje University

Status

Completed

Conditions

Pain, Postoperative

Study type

Observational

Funder types

Other

Identifiers

NCT00824772
00012007317-00

Details and patient eligibility

About

Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control. This study aims to reveal the genetic factors affecting the variable requirements of fentanyl during postoperative period.

Full description

The candidate genes are OPRM1, ABCB1,CYP3A4 and CYP3A5.

Enrollment

204 patients

Sex

Female

Ages

19 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients undergoing total abdominal hysterectomy (TAH) or laparoscopy assisted vaginal hysterectomy (LAVH) under general anesthesia
  • Patients who want to use intravenous patient controlled analgesia (PCA) after surgery
  • ASA physical status class I, II

Exclusion criteria

  • history of drug addiction
  • opioid medication within 12 hours before surgery
  • previous history of opioid medication for 3 months
  • neurologic disorder
  • cardiac disorder
  • hepatic disease
  • renal disease
  • respiratory disease such as COPD, asthma
  • sleep apnea
  • BMI > 30
  • psycotic disorder

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems