Evaluation of Post-extraction Socket Preservation With Camelline Versus Bovine Deproteinized Xenograft

Cairo University (CU)

Status and phase: Unknown; Early Phase 1

Conditions: Socket Preservation

Treatments: Procedure: socket preservation procedure

Study type: Interventional

Funder types: Other

Identifiers

NCT03677479

PER123

Details and patient eligibility

About

Alveolar ridge preservation following tooth extraction has the ability to maintain the ridge dimensions and allow the implant placement in an ideal position fulfilling both functional and aesthetic results. Postextraction socket healing commonly results in resorption of the alveolar ridge.

To prevent this clinical situation, different authors have described several surgical procedures, ranging from regenerative techniques for socket preservation to immediate implant placement. Regenerative techniques have been widely tested in controlled and uncontrolled studies with various materials and clinical approaches: bone grafting alone, including autografts, allografts, xenografts, and alloplasts; membrane alone, whether absorbable or not; and membrane in conjunction with grafting.

Full description

Various classic studies in the 1960s showed that the resorption process of the postextraction alveolus in both jaws was significantly more pronounced on the buccal aspect. This comes as no surprise, as the buccal surface of the anterior alveolar ridge is commonly thin and fragile. The maxilla tends to exhibit greater reductions in width than in height. The loss of tissue contour takes place mostly during the first 1 to 3 months following tooth extraction. Because the healing patterns of human sockets are unpredictable architecture), then such common procedures as extractions may lead to intraoral situations in which the remaining healed ridge does not allow for an esthetic and functional solution without the aid of significant bone grafting.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Teeth with: root fractures, endodontic treatment failures, advanced caries lesions or any other cause that make tooth non-restorable and indicated for extraction.
• Healthy non-smoker patients

Exclusion criteria

• Medically compromised patients.
• Pregnant females.
• History of malignancy or radiotherapy/chemotherapy for malignancy in the past 5 years.
• History of active bone metabolic disease.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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10 participants in 2 patient groups

socket preservation with camelline bone

Experimental group

Description:

natural hydroxyapatite derived from camels prepared by investigator

Treatment:

Procedure: socket preservation procedure

socket preservation with bovine bone

Active Comparator group

Description:

natural hydroxyapatite derived from cows (Bio-Oss)

Treatment:

Procedure: socket preservation procedure