Evaluation of Post Operative Pain in Retreatment of Molars Using Different Irrigant

Tamil Nadu Dr.M.G.R.Medical University

Status and phase: Unknown; Phase 1

Conditions: Root Canal Infection

Treatments: Drug: Sodium Hypochlorite

Study type: Interventional

Funder types: Other

Identifiers

NCT04250519

TamilNaduMU

Details and patient eligibility

About

This study evaluates the efficacy of dexamethasone as a intracanal irrigant along with sodium hypochlorite 1% and 5.25% concentrations in post treatment pain for molar root canal retreatment.

Full description

Main objective of root canal retreatment is to alleviate pain and disinfect the rootcanal .However some patients may experience mild to severe pain following treatment , which leads to intake of painkillers orally for post operative pain management.

So , this study evaluates the efficiency of dexamethasone used as intracanal irrigant in post treatment pain for molar root canal retreatment sodium hypochlorite (1% &5.25%) is used for disinfecting the canals patients will be grouped into Symptomatic and Asymptomatic patients requiring root canal retreatment and irrigants will be used in various combinations as mentioned below

1. 1% sodium hypochlorite alone 2.5ml in each canal along with ultrasonic activation
2. 1% sodium hypochlorite and dexamethasone 4mg,2.5ml in each canal along with ultrasonic activation
3. 5.25% sodium hypochlorite alone 2.5ml in each canal along with ultrasonic activation
4. 5.25% sodium hypochlorite and dexamethasone 4mg, 2.5ml in each canal along with ultrasonic activation calcium hydroxide is commonly used as intracanal medicament in all the patients post operative symptoms is evaluated at 12 hrs , 24 hrs,48 hrs, 72 hrs and 1 week followed by obturation is completed

Enrollment: 150 estimated patients

Sex: All

Ages: 15 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• teeth previously treated or attempted root canal treatment,
• teeth with or without symptoms,
• periapical radiograph showing evidence of inadequate previous root canal treatment or periapical changes,
• only teeth or at least one canal where complete removal of root canal filling material was possible and reach the working length in first appointment.

Exclusion criteria

• patient not willing for follow up,
• teeth with extensive cervical or apical resorption that restricted the use of sodium hypochlorite irrigation,
• teeth with poor periodontal status, teeth not suitable for post endodontic restoration,
• patients with acute periapical abscess,
• patients with systemic conditions preventing radiograph exposure or multi visit treatment,
• pregnant patients,
• patients with allergy to any known dental materials.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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150 participants in 4 patient groups

1% sodium hypochlorite & dexamethasone 4mg as irrigants

Experimental group

Description:

sodium hypochlorite is effective in any concentration as antimicrobial irrigant and dexamethasone is anti inflammatory drug

Treatment:

Drug: Sodium Hypochlorite

1% sodium hypochlorite as irrigant &normal saline as placebo

Active Comparator group

Description:

sodium hypochlorite is effective in any concentration as irrigant

Treatment:

Drug: Sodium Hypochlorite

5.25% sodium hypochlorite and dexamethasone 4mg as irrigants

Experimental group

Description:

sodium hypochlorite is effective in any concentration as antimicrobial irrigant and dexamethasone is anti inflammatory drug

Treatment:

Drug: Sodium Hypochlorite

5.25% sodium hypochlorite &normal saline as placebo

Active Comparator group

Description:

sodium hypochlorite is effective in any concentration as irrigant

Treatment:

Drug: Sodium Hypochlorite