Evaluation of Potential Biomarkers for Obstructive Sleep Apnea and the Effect of Positive Pressure Treatment

Karolinska University Hospital

Status: Completed

Conditions: Obstructive Sleep Apnea

Study type: Observational

Funder types: Other

Identifiers

NCT01976052

OSABiomarker

Details and patient eligibility

About

Potential biomarkers for obstructive sleep apnea (OSA), and full genomic screening will be evaluated and correlated to the degree of OSA and to effect of CPAP-treatment measured by polygraphy.

Full description

This project includes two parts:

• Genomic screening
• Biomarkers

Enrollment: 75 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

OSA-patients with moderate and severe OSA (n=15+15)

1. Adult, 18-75 years of age
2. Moderate (AHI 15-30) or Severe (AHI >30) OSA that are currently untreated and planned for CPAP-treatment
3. Otherwise healthy except for well controlled hypertension since 3 month, Max BP 140/90
4. Non-smokers
5. Not pregnant
6. No medications with antioxidants
7. BMI of <40

Controls (AHI<5) Two groups of controls

1. Matched controls The same age, sex and BMI ± 3 and eventual hypertension. These controls should also fulfill criteria 4-6 above.
2. Healthy controls with normal BMI (19-25) These controls should also fulfill criteria 1., 4-6 above.

Exclusion Criteria:

• If they no not fulfil the inclusion criteria

Trial design

75 participants in 3 patient groups

Obstructive sleep apnea patients

Description:

Patients with obstructive sleep apnea that has not received CPAP treatment

Matched volunteers with non OSA

Description:

Matched volunteers without OSA. Matched in respect to age and BMI

Matched normal controls with normal BMI

Description:

Volunteers that are matched according to age but has a normal BMI