Evaluation of Preexisting Immunity Markers in Human Tumor Tissue Sample

Stanford University

Status: Completed

Conditions: Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT00568867

SU-11072007-830

VAR0018 (Other Identifier)

97310 (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to evaluate markers of immune response in human tumor samples.

Full description

Cancer immunotherapy has been shown to be effective in isolated instances, but ineffective in most patients. The reason for this inconsistency, and the conditions necessary for successful immunotherapy, are not well understood. Our studies in animal tumor models indicate that the effectiveness of IL-12-based immunotherapy depends upon the presence of a preexisting immune response to the tumor. The presence of T cell infiltrates and IFN-gamma expression in tumor indicate such an immune response. We therefore plan to evaluate the existing immune response in human tumor samples in an effort to identify those patients most likely to respond to therapy with IL-12.

Enrollment: 300 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:Any adult patient with a tumor who is scheduled to undergo surgery to either remove or biopsy the tumor. Exclusion Criteria:Patients without tumor and pediatric patients (children) will be excluded.