Evaluation of Prognosis Factors of Neurological Evolution in Cardiac Arrest (ACR)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Cardio Respiratory Arrest

Treatments: Device: Synchronized Intermittent Mandatory Ventilation; Device: Pupillary light reflex surveillance; Other: Electroencephalography; Other: Therapeutic hypothermia; Device: Transcranial Doppler

Study type: Interventional

Funder types: Other

Identifiers

NCT02849561

38RC13.713

Details and patient eligibility

About

With the repercussion of 55 cases eachyear for 100 000 inhabitants in France, cardio respiratory arrest is a public health issue.

The goal of this study is to evaluate the pupillary light reflex measured by the dimension of the pupil (diameter) as a prognosis factor neurological evolution in post cardiac arrest. By participating to this study, the patient get the same tratments and exams than in a usual managing cares.

In addition of these events, the pupillary light reflex is studied as soon as the patient is accepted in the department, and then on the second day.

Currently, the evaluation of the neurological becoming rely on a multimodal clinical and paraclinical approach.

The study of the pupillary light reflex measured by the diameter of the pupil could be a prognosis factor of neurological evolution for patients in post cardiac arrest, so a reliable and available prognosis marker in patient care.

The goal of this study is to evaluate the pupillary light reflex (RPM), measured by the diameter of the pupil as a prognosis factor of neurological evaluation of admitted patients after a cardiac arrest.

Principal criteria of judgement is the percentage of the pupillary light reflex variation measured with Neurolight®, compared between two groups.

Enrollment: 82 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both gender
• Entry in resuscitation after a cardiac arrest intra or extra-hospital
• Resumption of a spontaneous cardiac activity
• Affiliation to a social security system

Exclusion criteria

• Refusal from patient or his family
• Age under 18 years
• Pregnant women
• Previous neurological damages
• Persons deprived of liberty by judicial or administrative decision

Trial design

82 participants in 2 patient groups

Favourable neurological evolution after cardiac arrest

Active Comparator group

Description:

MGOS 4-5

Treatment:

Device: Pupillary light reflex surveillance

Other: Therapeutic hypothermia

Device: Transcranial Doppler

Other: Electroencephalography

Device: Synchronized Intermittent Mandatory Ventilation

Unfavourable neurological evolution after cardiac arrest

Active Comparator group

Description:

MGOS 1-3

Treatment:

Device: Pupillary light reflex surveillance

Other: Therapeutic hypothermia

Device: Transcranial Doppler

Other: Electroencephalography

Device: Synchronized Intermittent Mandatory Ventilation