Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation. (ANIV)

Vaud University Hospital Center

Status: Unknown

Conditions: Lung Diseases; Non-invasive Ventilation; Healthy Volunteer; High-frequency Ventilation

Treatments: Device: High-frequency non-invasive ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02712190

ANIV

Details and patient eligibility

About

The purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.

Full description

High frequency ventilation (HF-V) allows to ensure oxygen delivery and carbon dioxide clearance despite the absence of thoracic movement in anesthetized, invasively ventilated subjects. This same technique could be applied by a non-invasive interface (HF-NIV), allowing to obtain a prolonged apnea (absence of thoraco-abdominal respiratory movements) in awaken subjects. Such an application would be of interest for several clinical applications, e.g. lung imaging and radio-therapy treatment on lung cancer. The purpose of the study is to assess the effect of different HF-NIV setting on the apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung diseases.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjets : normal respiratory function and no known lung disease
• lung disease patients : chronic obstructive pulmonary disease, Sarcoidosis, Cystic fibrosis
• age >=18y

Exclusion criteria

• increased pneumothorax risk under positive pressure ventilation
• pregnancy

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Low - High frequence sequence

Experimental group

Description:

High-Frequency non-invasive ventilation (HF-NIV) with 2 different settings, sequence of respiratory rate 250/min and respiratory rate 500/min

Treatment:

Device: High-frequency non-invasive ventilation

High - Low frequence sequence

Experimental group

Description:

High-Frequency non-invasive ventilation (HF-NIV) with 2 different settings, sequence of respiratory rate 500/min and respiratory rate 250/min

Treatment:

Device: High-frequency non-invasive ventilation