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Evaluation of Pulmonary Complications in Liver Transplantation Patients Based on Machine Learning

S

Sichuan University

Status

Enrolling

Conditions

Liver Transplantation

Study type

Observational

Funder types

Other

Identifiers

NCT06534840
2024HX8193

Details and patient eligibility

About

The main objective of this study is to develop a machine learning model that predicts moderate-severe prediction model of pulmonary complications in liver transplantation patients within 14 postoperative day using a real-world, local preoperative and intraoperative electronic health records, not administrative codes.

Full description

Postoperative pulmonary complications can increase the length of hospital stay and medical costs. In particular, moderate to severe pulmonary complications, which often require clinical intervention, once occur, will lead to significantly prolonged postoperative hospitalization or even cause permanent damage or death in severe cases. A number of risk-stratified cation models have been developed to identify patients at increased risk of postoperative pulmonary complications. However, these models were built by using the traditional regression analysis. However, the traditional prediction methods have the disadvantages of limited processing power of nonlinear models and outlier, and relatively single selection variables. The obtained models have poor accuracy, and the quantification degree is not enough, so it is difficult to popularize clinical application. Artificial machine learning can use it by analyzing a large number of specific features in the rich data set to identify and learn to accurately predict the diagnosis and prognosis of diseases, and surpass traditional prediction models in dealing with classification problems. The algorithms are flexible, and it is more and more widely used in clinical practice research. However, there are few reports on machine learning models predicting prognostic models related to postoperative pulmonary complications in liver transplantation patients. Therefore, we aimed to build predictive models using artificial machine learning methods to screen for their risk factors in order to provide early intervention and individualized treatment for high-risk patients.

Enrollment

400 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adult patients (age ≥ 18 years)
  • Undergoing liver transplantation

Exclusion criteria

  • Re-transplantation
  • Multi-organ transplants
  • Intra-operative deaths
  • severe encephalopathy (West Haven criteria III or IV)
  • Incomplete clinical data

Trial contacts and locations

1

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Central trial contact

Chun ling Jiang, PhD

Data sourced from clinicaltrials.gov

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