Evaluation of Rebound Effect After Withdrawal of Proton Pump Inhibitor in Geriatric Population

Fondation Hôpital Saint-Joseph

Status: Completed

Conditions: Proton Pump Inhibitor

Treatments: Drug: Antacids

Study type: Observational

Funder types: Other

Identifiers

NCT03467893

EGERIPP

Details and patient eligibility

About

Proton pump inhibitor are frequently used and are short term well tolerated ; but few studies show there are adverse event in long term prescription like fracture or pulmonary infection to Clostridum difficile. The fact is that multi medication in old patient increase the iatrogenic risk and decrease the medication compliance. The Proton pump inhibitor (PPI)are overused in this patient category.Several studies suggest the existence of a rebound effect when people were treated more than 8 weeks ; this effect seems to appear around 14 days after with hyperacidity symptoms.

But there are no studies about old patient. So in this context the aim of the study is to evaluate the prevalence of rebound effect occurence after the end of PPI 8 weeks treatment.

Enrollment: 30 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients hospitalized in post acute and rehabilitation service
• more than 65 years old
• PPI prescription more than 8 weeks

Exclusion criteria

• PPI prescription under 8 weeks
• PPI prescription for digestive haemorragy