Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy (CHESTOMY)

Università degli Studi di Ferrara

Status: Not yet enrolling

Conditions: Emergencies; Abdominal Sepsis; Ventilation Therapy; Complications; Acute Respiratory Failure

Treatments: Diagnostic Test: Intrabdominal pressure; Diagnostic Test: Arterial blood gas analysis; Diagnostic Test: Electrical impedance tomopgraphy; Diagnostic Test: Esophageal pressure monitoring; Diagnostic Test: Venous blood gas analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT05726500

CHESTOMY

Details and patient eligibility

About

The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis. The main question it aims to answer is:

• evaluate if patients admitted after an open abdomen strategy have a different regional ventilation distribution compared to patients in which abdomen is closed at the end of the procedure

Participants will undergo non-invasive monitoring (esophageal pressure and electrical impedance tomography) and an blood gas analysis samples.

Researchers will compare open abdomen group and closed abdomen group to see if the ventilation distribution pattern is different.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 and < 90 years
• Admitted to the ICU after emergent laparotomy for abdominal sepsis
• Acute respiratory failure

Exclusion criteria

• Controindications to electrical impedance tomography monitoring
• body mass index > 40 kg/m2
• Haemodinamic instability
• Pneumothorax - Pneumomediastinum
• refusal to participate

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Open Abdomen

Other group

Treatment:

Diagnostic Test: Electrical impedance tomopgraphy

Diagnostic Test: Intrabdominal pressure

Diagnostic Test: Arterial blood gas analysis

Diagnostic Test: Esophageal pressure monitoring

Diagnostic Test: Venous blood gas analysis

Closed Abdomen

Other group

Treatment:

Diagnostic Test: Electrical impedance tomopgraphy

Diagnostic Test: Intrabdominal pressure

Diagnostic Test: Arterial blood gas analysis

Diagnostic Test: Esophageal pressure monitoring

Diagnostic Test: Venous blood gas analysis