Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation (WEAN-EIT)

Università degli Studi di Ferrara

Status: Enrolling

Conditions: Weaning Failure; Mechanical Ventilation Complication; Ventilator-Induced Lung Injury; Acute Respiratory Failure

Treatments: Diagnostic Test: Weaning trial - Low support, zero positive end-expiratory pressure; Diagnostic Test: Weaning trial - Zero support, zero positive end-expiratory pressure; Diagnostic Test: Weaning trial - Low support, high Positive end-expiratory pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT05726513

WEAN-EIT

Details and patient eligibility

About

The goal of this physiological cross-over clinical trial is to evaluate the effect of different clinically used weaning trials on regional mechanical ventilation in a population of patients undergoing weaning from mechanical ventilation for acute respiratory failure.

The main question[s] it aims to answer are:

• to evaluate which weaning trial is associated to a better regional ventilation distribution
• to evaluate which weaning trial can be comparable to ventilation distribution after extubation

Participants will undergo 3 clinically used weaning trials in a random order (cross-over trial). Researchers will compare the different steps to see if regional ventilation distribution is different among the different trial .

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 and < 70 years
• Ready to be weaned from mechanical ventilation according to clinical criteria

Exclusion criteria

• Age < 18 years or > 70 years
• Presence of chest drains
• Presence of pacemaker/impantable cardiac device;
• diagnosis of Pneumothorax, or pneumomediastinum
• Diagnois of neuromuscular diseases
• Use of neuromuscular blockers in the 48 hours before screening;
• Body mass index > 35 kg/m2
• Refusal to participate of the patient/next of kin

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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30 participants in 3 patient groups

Low support, high Positive end-expiratory pressure

Other group

Description:

Low support, high Positive end-expiratory pressure

Treatment:

Diagnostic Test: Weaning trial - Low support, high Positive end-expiratory pressure

Low support, zero positive end-expiratory pressure

Other group

Description:

Low support, zero positive end-expiratory pressure

Treatment:

Diagnostic Test: Weaning trial - Low support, zero positive end-expiratory pressure

Zero support, zero positive end-expiratory pressure

Other group

Description:

Zero support, zero positive end-expiratory pressure

Treatment:

Diagnostic Test: Weaning trial - Zero support, zero positive end-expiratory pressure