Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid

Cairo University (CU)

Status: Completed

Conditions: Oral Lichen Planus

Treatments: Drug: Triamcinolone Acetonide in orabase

Study type: Observational

Funder types: Other

Identifiers

NCT03871114

miR-155 OLP

Details and patient eligibility

About

Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients. Oral lichen planus patients will be treated with a topical steroid and miR-155 and IL-10 will be assessed in saliva before and after 4 weeks of topical steroids use

Enrollment: 30 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients clinically and histopathologically diagnosed as having atrophic/erosive OLP.
• Patients free from any other oral lesions
• cooperative patients who agrees to take the supplied medications.
• Patients who are systemically healthy

Exclusion criteria

• Patients suffering from any systemic disease.
• Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
• Treatment with any oral topical medications for at least four weeks prior to the study.
• Pregnant and lactating women.

Trial design

30 participants in 2 patient groups

OLP patients

Description:

fifteen patients with atrophic /erosive OLP will receive treatment with topical triamcinolone acetonide in orabase 1mg/g 3 times /day and assessed every week for 4 weeks

Treatment:

Drug: Triamcinolone Acetonide in orabase

Control group