Evaluation of Salt Status in Patients With Cystic Fibrosis

Ghent University Hospital (UZ)

Status: Completed

Conditions: Salt; Deficit (or Low); Cystic Fibrosis

Treatments: Other: risk subgroups; Diagnostic Test: fractional sodium excretion

Study type: Observational

Funder types: Other

Identifiers

NCT04556162

BC-05673

Details and patient eligibility

About

The results of the annual check-up will be collected to evaluate the best urinary marker for fractional sodium excretion and salt status will be correlated to clinical outcome measures.

Full description

Patients with cystic fibrosis need extra salt as they have increased losses through sweat. Current advices are to follow and supplement if needed, however the way to follow salt depletion is unclear.

The best way is to calculate fractional salt excretion. This needs a simultaneous blood and urine sample for electrolytes and creatinin. Urinary surrogate markers have been validated on only 10 patients.

At the annual check-up patients with cystic fibrosis receive these measurements. The investigators will collect the measurements and calculate fractional excretion and the possible surrogate markers on urine. Further this will be correlated to nutritional and pulmonary status and patient subgroups at risk will be identified.

Enrollment: 222 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• all cystic fibrosis patients followed at the Gent University Cystic fibrosis centre
• Providing a paired urine and blood sample at the time of their annual check-up

Exclusion criteria

• transplantation