Evaluation of Serological Markers of Vitiligo Activity

Hospital de Clinicas de Porto Alegre

Status: Active, not recruiting

Conditions: Vitiligo

Study type: Observational

Funder types: Other

Identifiers

NCT06731283

2022-0610

Details and patient eligibility

About

The goal of this case-control study is to evaluate the possible applicability of CXCL10, CXCL9, CCL20, and homocysteine as biomarkers of disease activity in vitiligo patients and to compare the levels of these markers with those in healthy controls.

Full description

The diagnosis and prognosis assessment in patients with vitiligo are essentially clinical. There are still no validated and established serological markers to objectively assist in defining disease activity. Objective: To evaluate the potential use of the biomarkers CXCL9, CXCL10, CCL20, S100B, and homocysteine to identify disease activity in vitiligo, comparing their values with controls. Methods: A case-control study using previously collected peripheral blood samples from patients aged 18 years or older with a diagnosis of vitiligo and from controls without the disease. The project was approved by the institution's ethics committee. Tests were conducted using ELISA and Luminex kits to measure CXCL9, CXCL10, CCL20, and S100B. For homocysteine, the chemiluminescence method was used.

Enrollment: 85 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Vitiligo
• Older than 18 years

Exclusion criteria

• Not having diagnosis of vitiligo
• Less than 18 years

Trial design

85 participants in 2 patient groups

Vitiligo

Description:

Patients diagnosed with vitiligo

Controls

Description:

Patients that do not have vitiligo