Evaluation of Serum Procalcitonin Rate in Patients With Stage IV Non-small Cell Lung Cancer in First Line Chemotherapy (KBPCT)

Centre Hospitalier Universitaire, Amiens

Status

Unknown

Conditions

Non Small Cells Lung Cancer

Treatments

Biological: PCT dosage

Study type

Observational

Funder types

Other

Identifiers

NCT02821949

PI2014_843_0012

Details and patient eligibility

About

Treatment of a stage IV NSCLC is based on chemotherapy and requires before each session to check clinically, biologically and radiologically absence of infection. This biological evaluation is based on the CRP rate. Lots of infections may occur in this situation and could reduce by three the patient's life duration. However it is very important to make as early as possible a correct diagnosis of infection. CRP rate is classically higher for those patients even without any infection. In comparison with CRP, Procalcitonin (PCT) is well-known for its better sensibility and specificity for the infection diagnosis but has never been study in case of active cancer. The aim of this study is to evaluate the Procalcitonin basal rate for those patients suffering from NSCLC. It could be a simple and reliable method to use. So the investigators decided to include each new patient with NSCLC stage IV coming for his first-line chemotherapy without any infection sign, and to realize a Procalcitonin dosage before the start of the treatment. This sample will be analyzed at the chemical laboratory and the result will not be communicated to the patient physician. A new clinical evaluation will be realized either at the hospital or by phone at day 7 to search any sign of infection. In absence of infection, patient will be reevaluated at day 14, 21 and 30. In case of infection, a new Procalcitonin (and CRP) dosage will be performed.

Enrollment

50 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient with stage IV NSCLC, hospitalized for his first seance of chemotherapy
Medical conditions permitting chemotherapy
Informed consent signed
Patient covered by social insurance

Exclusion criteria

Patient with small cell lung cancer
Patients with NSCLC stage I, II or III of the Tumor Node Metastasis classification
Patient with stage IV NSCLC, who received prior treatment (radiotherapy, chemotherapy ...)
Patient with infection (on clinical and paraclinical criteria) not compatible with the administration of the first seance of chemotherapy.
Pregnant or breastfeeding women Private Patient freedom or in a position to judicial protection (guardianship)