Evaluation of Sticky Bone With or Without EDTA for Treatment of Gingival Recession

Kafrelsheikh University

Status: Enrolling

Conditions: Gingival Recession

Treatments: Procedure: Sticky bone; Procedure: Sticky bone and EDTA

Study type: Interventional

Funder types: Other

Identifiers

NCT04980066

KD/10/21

Details and patient eligibility

About

Gingival recession is a common clinical finding in periodontal disease which is frequently associated with esthetic concerns, root hypersensitivity, and root caries. Many surgical therapeutic approaches have been developed to predictably obtain root coverage of gingival recession defects. Injectable PRF (I-PRF) is the liquid form of PRF. I-PRF is a bioactive agent obtained by low-speed centrifugation, and it has the capacity to stimulate tissue regeneration. At high concentrations, PRF may stimulate the secretion of several growth factors and trigger fibroblast migration. I-PRF is generally used in regenerative treatments, with good outcomes. Ethylenediaminetetraaceti acid (EDTA) is a chelating agent that could enhance the attachment of connective tissue to the root surface by exposing collagen and, as a consequence, enhance root coverage. EDTA works at neutral pH, and this property has been reported to preserve adjacent tissue vitality. The present study will be carried out to evaluate the effect of sticky bone with or without EDTA root surface biomodification for treatment of gingival recession.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Miller I/II isolated maxillary recession defects.
• No abrasion, caries, or cervical restorations and presence of identifiable cementoenamel junction (CEJ).
• No occlusal interferences.
• Full-mouth plaque index (PI) and gingival index (GI) scores of < 1.
• Non-smokers.

Exclusion criteria

• Pregnant patients
• Presence of systemic disease or taking medication that interfere with periodontium

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

sticky bone and EDTA

Experimental group

Description:

treatment of gingival recession using sticky bone after root surface biomodification with EDTA

Treatment:

Procedure: Sticky bone and EDTA

Sticky bone

Active Comparator group

Description:

treatment of gingival recession using sticky bone

Treatment:

Procedure: Sticky bone