Evaluation Of Stress Response In Diabetic Hypertensive Patients

Istanbul University

Status: Completed

Conditions: Hypertension; Diabetes

Treatments: Behavioral: Third arithmetic problem solving; Behavioral: Second arithmetic problem solving; Behavioral: Fifth arithmetic problem solving; Behavioral: First arithmetic problem solving; Behavioral: Fourth arithmetic problem solving; Behavioral: Sixth arithmetic problem solving

Study type: Observational

Funder types: Other

Identifiers

NCT05662930

22939

Details and patient eligibility

About

In this research, we aimed to examine salivary cortisol changes in the cognitive stress response of patients with Hypertension + Diabetes Mellitus (HT+DM) and Hypertension (HT) and to determine the differences between them.

The research was conducted by solving an arithmetic task as a stress test in 62 patients with HT+DM and HT that are being treated in the outpatient clinic of Medical Pharmacology and Clinical Pharmacology Department at Istanbul University, Istanbul Medical Faculty Hospital.

Full description

In this study, saliva samples were taken for cortisol measurement, and patients were instructed to place the cotton piece in the salivette® tubes directly into their mouths without touching it with anything, hold it for 30-60 seconds, and then insert it back into the tubes in the same way, four times total, once before arithmetic stress and three times after stress, on Tuesdays, Wednesdays, and Thursdays between the hours of 12:00-16:00.

Salivary cortisol was measured using the electro-chemiluminescence immunoassay.

Enrollment: 62 patients

Sex: Male

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Using antihypertensive treatment for the last 3 months
2. Diagnosed with Type 2 Diabetes Mellitus and taking medication for at least 3 months
3. Being between the ages of 40-65
4. Being male
5. Having signed the informed consent form

Exclusion criteria

1. Female gender
2. Patients younger than 40 years old or older than 65 years old
3. Uncontrolled blood pressure (SBP>140 mmHg, DBP>90 mmHg)
4. Using antipsychotic medication
5. Using current treatment for less than 3 months
6. Having a previous MI
7. Having a previous stroke
8. Having a lung disease
9. Having organ failure
10. Having Cushing's disease
11. Having aldosteronism
12. Failure to sign the informed consent form

Trial design

62 participants in 2 patient groups

Hypertension + Diabetes Mellitus (HT+DM)

Description:

Patients who fulfilled the following criteria were included in this group: 1. Using antihypertensive treatment for the last 3 months 2. Diagnosed with Type 2 Diabetes Mellitus and taking medication for at least 3 months 3. Being between the ages of 40-65 4. Being male 5. Having signed the informed consent form

Treatment:

Behavioral: Third arithmetic problem solving

Behavioral: First arithmetic problem solving

Behavioral: Fifth arithmetic problem solving

Behavioral: Second arithmetic problem solving

Behavioral: Fourth arithmetic problem solving

Behavioral: Sixth arithmetic problem solving

Hypertension (HT)

Description:

Patients who fulfilled the following criteria were included in this group: 1. Using antihypertensive treatment for the last 3 months 2. Being between the ages of 40-65 3. Being male 4. Having signed the informed consent form

Treatment:

Behavioral: Third arithmetic problem solving

Behavioral: First arithmetic problem solving

Behavioral: Fifth arithmetic problem solving

Behavioral: Second arithmetic problem solving

Behavioral: Fourth arithmetic problem solving

Behavioral: Sixth arithmetic problem solving