Evaluation of Surfactant Protein B in the Differential Diagnostics of Dyspnea

Universitätsmedizin Mannheim

Status: Completed

Conditions: Dyspnea; Cardiac Disease; Pulmonary Disease

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01197586

2010_spb_ma

Details and patient eligibility

About

Establishing new biochemical markers in the differential diagnostics and risk stratification in heterogeneous patient collectives is becoming more and more important. The markers should be objective, reliable, reproducible, quick and cost effective as well as specific and sensitive. Concerning the differential diagnostics of "dyspnea", NT-pro-BNP plays the most important role for the evaluation of a cardiac origin. However, a corresponding biochemical marker for pulmonary stress is lacking. The aim of the study at hand therefore was the evaluation of surfactant protein B in the differential diagnostics of pulmonary and cardiac diseases.

Enrollment: 55 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients presenting with dyspnea and giving informed consent

Exclusion criteria

• outpatients
• lack or doubt of legal competence
• indication for mechanical ventilation
• pregnancy
• palliative patients
• CPAP/LTOT
• BMI > 30 kg/m2
• sepsis
• anemia
• dialysis