Evaluation of Surgical Stress Index (SSI) During Sevoflurane/Remifentanil Anesthesia

University Hospital Schleswig-Holstein (UKSH)

Status: Completed

Conditions: Analgesia

Treatments: Procedure: standardized pain stimulus

Study type: Interventional

Funder types: Other

Identifiers

NCT00791791

SSI-134-1

Details and patient eligibility

About

The aim of the present prospective randomized study was to challenge the ability of SSI to detect painful stimulation during sevoflurane - remifentanil anesthesia.

Full description

General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Whereas monitoring of depth of hypnosis, and muscle relaxation can be regarded as accepted, determination of the nociception is based on clinical signs like somatic or autonomic responses.

Recently, the multivariate surgical stress index (SSI)has been demonstrated to correlate with surgical stress intensity. Thus, SSI might be a useful variable to adjust analgesic drug administration in individual patients.

We want to investigate whether SSI is able to indicate nociception following standardized noxious stimulation during balanced sevoflurane - remifentanil anesthesia.

Enrollment: 24 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between 18 and 65 years
• ASA physical status 1-2
• elective surgery in general anesthesia of 1 to 2 hours
• written informed consent

Exclusion criteria

• pregnancy
• history of cardiac arrhythmia
• presence of any neuromuscular or neurological disease
• use of CNS-active medication or abuse of alcohol or illicit drugs

Trial design

24 participants in 2 patient groups

1

Other group

Description:

increasing remifentanil administration

Treatment:

Procedure: standardized pain stimulus

2

Other group

Description:

decreasing remifentanil concentration

Treatment:

Procedure: standardized pain stimulus