Evaluation of Systemic Microvascular Reactivity After Ingestion of an Energy Drink in Young Male Volunteers

National Institute of Cardiology, Laranjeiras, Brazil

Status: Completed

Conditions: Endothelial Function

Treatments: Dietary Supplement: Ingestion of the energy drink (Red Bull®); Dietary Supplement: Ingestion of mineral water

Study type: Observational

Funder types: Other

Identifiers

NCT05575895

CAAE 13135219.0.0000.5272

Details and patient eligibility

About

Purpose: Energy drinks (EDs) are nonalcoholic beverages whose main ingredients are sugar, taurine, and caffeine. Their consumption is rising worldwide, with only few conflicting studies examining their vascular effects in young adults. We evaluated microvascular reactivity (MR) before and after ED in young healthy male volunteers.

Methods: Systemic MR was evaluated in the skin of the forearm using laser speckle contrast imaging with acetylcholine (ACh) iontophoresis before, 90 and 180 minutes after the consumption of one can of ED or the same volume of water (control), followed by postocclusive reactive hyperemia (PORH).

Full description

Energy drinks (EDs) are nonalcoholic beverages whose main ingredients are sugar, taurine, and caffeine. These products are marketed as boosters of mental and physical performance and are increasingly used in Western societies. Case reports of adverse effects related to ED consumption have been described in healthy young individuals, including coronary artery vasospasm, and myocardial infarction. These data suggest that endothelial dysfunction (EDysf) plays a role in ED cardiovascular effects and have prompted studies with conflicting results. The present study evaluated the microvascular reactivity (MR) after ingestion of one can of ED compared to a control, in young healthy male volunteers.

Enrollment: 22 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy male volunteers with no relevant findings in the medical history

Exclusion criteria

• being a competitive athlete;
• being on regular medication;
• using illicit drugs;
• being allergic to coffee, taurine or any of the components of the selected energy drink; - -
• having a body mass index ≥ 30 kg/m2.

Trial design

22 participants in 2 patient groups

Energy Drink

Description:

Ingestion of 250 ml of the energy drink (Red Bull®) - Evaluation of systemic skin microvascular endothelial function Laser-based method for evaluating non-invasive, operator-independent systemic microvascular function that detects microvascular flow in the skin for the evaluation of systemic vascular endothelial function.

Treatment:

Dietary Supplement: Ingestion of the energy drink (Red Bull®)

Control

Description:

Ingestion of 250 ml of mineral water (Minalba®) - Evaluation of systemic skin microvascular endothelial function Laser-based method for evaluating non-invasive, operator-independent systemic microvascular function that detects microvascular flow in the skin for the evaluation of systemic vascular endothelial function.

Treatment:

Dietary Supplement: Ingestion of mineral water