Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection

Centro Universitario de Lavras

Status: Completed

Conditions: Chronic Periodontitis; Periodontal Disease

Treatments: Drug: Chlorhexidine gel and gluconate; Procedure: Scaling and root planing; Drug: Chlorhexidine gluconate solution; Procedure: Full mouth disinfection; Drug: Azithromycin

Study type: Interventional

Funder types: Other

Identifiers

NCT02126267

07172212.3.0000.5149

Details and patient eligibility

About

Evaluate and compare the effectiveness in a clinical and microbial perspective one stage full-mouth disinfection technique in relation to scaling and root planing per quadrant associated with chlorhexidine or azithromycin.

Full description

Seventy -seven systemically healthy subjects with chronic periodontitis were randomly included in 6 different predefined groups. The following periodontal parameters were evaluated: probing depth , clinical attachment level , plaque index, gingival index and percentage of areas affected by periodontal disease. Microbiologically were evaluated the bacterial load and specific load of five bacterias: The quantification of the bacteria was performed by real-time Polymerase Chain Reaction . The clinical and microbial baseline evaluations were performed ( periodontal pre- therapy) , 90 and 180 days after treatment.

Enrollment: 77 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of slight-moderate chronic periodontitis

Exclusion criteria

• Those who were making regular use of antibiotics or anti-inflammatory drugs or had done up to three months before the beginning of the study;
• those who were making regular use (twice a day) of oral rinses with chlorhexidine or essential oils or have made regular use within three months prior to study entry;
• individuals with a history of sensitivity to chlorhexidine or azithromycin;
• subjects undergoing periodontal therapy include dental scaling procedures in the 12 months preceding the start of the study;
• subjects with impaired bifurcation or trifurcation class III;
• who required antibiotic prophylaxis for conducting clinical periodontal examination
• subjects with removable partial dentures and removable or fixed orthodontic appliance.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

77 participants in 6 patient groups

Full mouth disinfection - FMD

Experimental group

Description:

n = 10: Procedures for scaling and root planing were performed in a single stage (24 hours) divided into two sessions (60 min per session) on two consecutive days

Treatment:

Procedure: Full mouth disinfection

FMD + chlorhexidine (FMD-CX)

Experimental group

Description:

n = 15: Same as FMD with the inclusion of chlorhexidine in office (application of chlorhexidine (CX) (1%) gel in pockets after scaling, brushing tongue for 1 min. with CX (1%) gel and mouthwash at the beginning and end of each session with CX 0.2% for 30 seconds (with the form of a gargle in the last 10 seconds)). In addition, use was made of homemade CX 0.2% for 60 days after the scaling in a single phase.

Treatment:

Procedure: Full mouth disinfection

Drug: Chlorhexidine gluconate solution

Drug: Chlorhexidine gel and gluconate

FMD + azithromycin (FMD-AZ)

Experimental group

Description:

n = 15: Same as with the FMD include the use of azithromycin (500 mg) once daily for 3 consecutive days. Medication was started the same day as the end of the scaling.

Treatment:

Procedure: Full mouth disinfection

Drug: Azithromycin

Scaling and root planing (SRP)

Experimental group

Description:

(n = 13): scaling procedures were performed per quadrant (30 min. per quadrant) at weekly intervals between sessions;

Treatment:

Procedure: Scaling and root planing

SRP + azithromycin (SRP-AZ)

Experimental group

Description:

n = 11: Same as scaling and root planing group (SRP) with inclusion of the use of azithromycin (500 mg) once daily for 3 consecutive days. Medication was started the same day as the end of the last scaling hemi-arch;

Treatment:

Drug: Azithromycin

Procedure: Scaling and root planing

SRP + chlorhexidine (SRP-CX)

Experimental group

Description:

n = 13 : Same as group scaling and root planing (SRP) with the inclusion of home use of CX 0.2% for 60 consecutive days after the end of the first session of scaling

Treatment:

Drug: Chlorhexidine gluconate solution

Procedure: Scaling and root planing