Evaluation Of The Chronic Effects Of Covıd-19 Infection On The Respiratory System

Yeditepe University

Status

Completed

Conditions

COVID-19

Post-COVID-19 Syndrome

Treatments

Diagnostic Test: Pulmonary Ultrasound, Respiratory Function Test

Study type

Observational

Funder types

Other

Identifiers

NCT06439134

Inflammation and Post COVID-19

Details and patient eligibility

About

The aim of this study is to evaluate whether there are chronic effects in the pulmonary system and systemic level in individuals in the post COVID19 period in order to elucidate the involvement of inflammation after recovery. In addition, a perspective on the utility of pulmonary function testing and pulmonary ultrasound in the evaluation of chronic effects and patient follow-up will is aimed to be provided. By measuring the protein levels of inflammatory markers along with the data abovementioned, a foresight regarding the long-term effects of the previous infection at both functional and immunological levels will be obtained, allowing us to evaluate the post-COVID period from different angles.

Volunteers who recovered from COVID-19 and those who didn't have COVID-19 were compared by evaluating chest x-ray scores (CXR), lung ultrasound scores (LUSS), pulmonary function tests and inflammatory cytokine levels (TNF-α, IL-1, IL-6, IL-17A).

Full description

Objective: The aim of this study is to evaluate whether there are chronic effects in the pulmonary system and systemic level in individuals in the post COVID19 period in order to elucidate the involvement of inflammation after recovery. In addition, a perspective on the utility of pulmonary function testing and pulmonary ultrasound in the evaluation of chronic effects and patient follow-up will is aimed to be provided. By measuring the protein levels of inflammatory markers along with the data abovementioned, a foresight regarding the long-term effects of the previous infection at both functional and immunological levels will be obtained, allowing us to evaluate the post-COVID period from different angles.

Materials and Methods: Volunteers who recovered from COVID-19 infection at least 3 months or more were included in the study, while healthy volunteers who did not have the infection were enrolled as the control group. Two groups were compared by evaluating chest x-ray scores (CXR), lung ultrasound scores (LUSS), pulmonary function tests and inflammatory cytokine levels (TNF-α, IL-1, IL-6, IL-17A).

Enrollment

100 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:For the control group;

Age range: 18-60 years old
Not having had COVID-19 infection
(For female patients) No pregnancy or puerperium
Consent for the study
To be able to complete the pulmonary function test successfully
Vital signs at the stage of lung ultrasound or pulmonary function testing during the study no change in findings
Not having an active infection at the time of the workplace examination
No abnormal findings in the chest radiograph taken before the study
Absence of existing autoimmune or rheumatological disorders For the experimental group;
Age range: Being between 18-60 years old
Having had COVID-19 infection and post infectious period of 3 months or more to be
(For female patients) No pregnancy or puerperium
Consent for the study
To be able to complete the pulmonary function test successfully
Vital signs at the stage of lung ultrasound or pulmonary function testing during the study no change in findings
Not having an active infection at the time of the workplace examination
Abnormal findings on chest radiography taken in the pre-infectious period before the study absence of
Absence of existing autoimmune or rheumatological disorders

Exclusion Criteria:

Age range: Being outside the 18-60 age range
(for the experimental group) COVID-19 infection and 3 days of post infectious period under the month
(For female patients) Pregnancy or puerperium
Lack of consent for the study
Failure to complete the pulmonary function test (dizziness, incompatibility, etc.) reasons)
Vital signs at the stage of lung ultrasound or pulmonary function testing during the study change in findings
Having an active infection at the time of the workplace examination
Abnormal chest radiographs taken in the pre-infectious period before the study the presence of findings
Existing autoimmune or rheumatological disease