Effects of Chlorhexidine Toothpaste on Wound Healing After Impacted Tooth Extraction

Yuzuncu Yıl University

Status: Completed

Conditions: Tooth Impaction; Tooth Diseases

Treatments: Procedure: Surgery of impacted mandibular wisdom teeth

Study type: Interventional

Funder types: Other

Identifiers

NCT06067542

YYU-04/04.03.2020

Details and patient eligibility

About

In this study, the postoperative clinical and microbiologic effects of chlorhexidine toothpaste and chlorhexidine-free toothpaste with the same content were compared after bilateral mandibular impacted third molar surgery. Similarly positioned fully impacted impacted lower third molars were extracted. Bilateral impacted wisdom teeth of the patients were randomly selected. After the operation, the experimental group received Dentasave 0.2% chlorhexidine toothpaste containing chlorhexidine and the control group received toothpaste with the same content but without chlorhexidine. Teeth were extracted by the same dentist at 14-day intervals. For microbiological analysis, saliva samples were taken before the first tooth extraction, before the second tooth extraction 14 days later and on the 28th day and sent to the microbiology laboratory. Wound healing, edema and trismus in both extractions were evaluated 1 week after tooth extraction. Wound healing was evaluated as good, acceptable and poor. VAS (Visual Analog Scale) was used for pain assessment and recorded 14 days after tooth extraction.

Enrollment: 22 patients

Sex: All

Ages: 18 to 31 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Volunteers with bilateral fully impacted mandibular wisdom teeth

Exclusion criteria

• Patients were excluded from the study if they did not understand the clinical procedures of the study,
• Had allergies or intolerance to any of the substances used in the study,
• Patients on anticoagulant or psychiatric treatment,
• Pregnant or breastfeeding,
• Patients using oral contraceptiveswere,
• Diabetic,
• Patients with periodontal disease or active infection
• Smokers of more than 10 cigarettes per day,
• Poor oral hygiene

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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22 participants in 2 patient groups, including a placebo group

Study group using chlorhexidine toothpaste after wisdom tooth extraction

Experimental group

Description:

22 patients, 17 females and 5 males, 44 bilateral, similarly positioned fully impacted impacted lower third molars were extracted. Bilateral impacted wisdom teeth of the patients were randomly selected. After the operation, the experimental group received Dentasave 0.2% chlorhexidine toothpaste containing chlorhexidine

Treatment:

Procedure: Surgery of impacted mandibular wisdom teeth

Control group using chlorhexidine-free toothpaste after wisdom tooth extraction

Placebo Comparator group

Description:

Bilateral impacted wisdom teeth of the patients were randomly selected. After the operation, the control group was given toothpaste with the same ingredients as the study group but without chlorhexidine.

Treatment:

Procedure: Surgery of impacted mandibular wisdom teeth