Evaluation of the Clinical Relationship Between Procalcitonin Level and Bacteremia Agent in Intensive Care Unit Patients

Gulhane Training and Research Hospital

Status: Active, not recruiting

Conditions: Septic; Procalcitonin; Bacteremia and Sepsis; Intensive Care Medicine; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT06958354

2023/34

Details and patient eligibility

About

In intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality. Early recognition of sepsis and appropriate antibiotic use for the causative agent is one of the most important steps in the fight against sepsis. Procalcitonin (PCT) is a calcitonin precursor peptide and has been reported to predict bacteremia early. While the PCT concentration level is negligible in healthy individuals, it has been shown to increase especially in bacterial infections, sepsis, trauma and burns. In our study, our aim is to determine whether there is a relationship between serum PCT concentration levels taken within 24 hours according to the time of the sample taken for blood culture with growth in patients followed up in our Internal Intensive Care Unit.

Enrollment: 1,529 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Positive blood culture during their follow up
• Patients over 18 years of age

Exclusion criteria

• Those under the age of 18
• Those who have had surgery or trauma in the last 72 hours
• Those with a history of autoimmune disease, chronic renal failure
• Patients admitted to intensive care due to acute pancreatitis, pregnancy, burns.
• Patients with incomplete data.