Evaluation of the Consequences of Poly Vaccination on Innate Immunity : Applications to a Military Population (VaxInnate)

Direction Centrale du Service de Santé des Armées

Status: Not yet enrolling

Conditions: Vaccine Breakthrough Infections

Treatments: Other: Blood and saliva sampling; Other: Survey

Study type: Observational

Funder types: Other

Identifiers

NCT06110741

2023-A01356-39 (Other Identifier)

2023PPRC01

Details and patient eligibility

About

In this study, the poly vaccination of military personnel prior to deployment will be analyzed in terms of central, peripheral and long-lasting changes in innate immunity.

Analysis of monocyte immune training induced by vaccination will provide a better understanding of the indirect effects of vaccination and their persistence over time.

Enrollment: 410 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• french military personnel
• >18yo
• overseas deployment scheduled between 30 and 60 days after vaccination session
• adult
• able to give consent

Exclusion criteria

• unrectified military personnel
• having received a live vaccine within 6 months prior to inclusion
• having received an attenuated vaccine within 3 months prior to inclusion
• pregnancy or breastfeeding
• vaccine contraindication
• major incapacity

Trial design

410 participants in 2 patient groups

Sampling and survey group

Description:

This group will complete questionnaires and participate in sample collection.

Treatment:

Other: Survey

Other: Blood and saliva sampling

Survey group

Description:

This group will only complete questionnaires

Treatment:

Other: Survey