Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation

M

Mongi Slim Hospital

Status

Enrolling

Conditions

Mechanical Ventilation Weaning

Treatments

Diagnostic Test: diaphragm ultrasound monitoring

Study type

Observational

Funder types

Other

Identifiers

NCT06203353
Diaphram Tissue Doppler

Details and patient eligibility

About

Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest level of pressure support). Before separating the patient from the ventilator and performing a T tube spontaneous breathing test, diaphragm ultrasound is performed bilaterally : diaphragm excursion, diaphragm thickening fraction and maximal contraction and relaxation velocities with tissue doppler imaging.

Full description

This observationnal study will include patients during weaning from invasive mechanical ventilation: ventilation in pressure support with the lowest level With normal neurological status: glasgow coma scale > 13 Requiring no vasopressor support conventionnal diaphragm parameters: diaphram excursion and thickening fraction will be collected bilaterally with the tissue doppler measures: maximal contraction and relaxation velocities, immediately before a T Tube test. Patients will be divided into 2 groups according to their weaning from mechanicla ventilation outcome, and diaphragm ultrasound patterns will be compared between the 2 groups in order to evaluate the performance of tissue doppler in predicting weaning outcome.

Enrollment

50 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Invasive mechanical ventilation for at least 48 hours

Exclusion criteria

  • reintubation for extra respiratory failure (neurologic or hemodynamic)
  • Patients with chronic repiratory failure

Trial design

50 participants in 2 patient groups

weaning success
Description:
Patients extubated with no need to non invasive ventilatry support during 48 hours
Treatment:
Diagnostic Test: diaphragm ultrasound monitoring
weaning failure
Description:
patients requiring reintubation or non invasive ventilation within 48 hours after extubation
Treatment:
Diagnostic Test: diaphragm ultrasound monitoring

Trial contacts and locations

1

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Central trial contact

Mhamed Mebazaa, professor; Asma Ben Souissi, Asso Prof

Data sourced from clinicaltrials.gov

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