Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation

Mongi Slim Hospital

Status: Enrolling

Conditions: Mechanical Ventilation Weaning

Treatments: Diagnostic Test: diaphragm ultrasound monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT06203353

Diaphram Tissue Doppler

Details and patient eligibility

About

Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest level of pressure support).

Before separating the patient from the ventilator and performing a T tube spontaneous breathing test, diaphragm ultrasound is performed bilaterally : diaphragm excursion, diaphragm thickening fraction and maximal contraction and relaxation velocities with tissue doppler imaging.

Full description

This observationnal study will include patients during weaning from invasive mechanical ventilation: ventilation in pressure support with the lowest level With normal neurological status: glasgow coma scale > 13 Requiring no vasopressor support

conventionnal diaphragm parameters: diaphram excursion and thickening fraction will be collected bilaterally with the tissue doppler measures: maximal contraction and relaxation velocities, immediately before a T Tube test.

Patients will be divided into 2 groups according to their weaning from mechanicla ventilation outcome, and diaphragm ultrasound patterns will be compared between the 2 groups in order to evaluate the performance of tissue doppler in predicting weaning outcome.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Invasive mechanical ventilation for at least 48 hours

Exclusion criteria

• reintubation for extra respiratory failure (neurologic or hemodynamic)
• Patients with chronic repiratory failure

Trial design

50 participants in 2 patient groups

weaning success

Description:

Patients extubated with no need to non invasive ventilatry support during 48 hours

Treatment:

Diagnostic Test: diaphragm ultrasound monitoring

weaning failure

Description:

patients requiring reintubation or non invasive ventilation within 48 hours after extubation

Treatment:

Diagnostic Test: diaphragm ultrasound monitoring