Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash

Medical University of South Carolina (MUSC)

Status: Completed

Conditions: Arthropathy of Hip; Arthropathy of Knee

Treatments: Drug: EPI75 group; Drug: EPI50 group; Drug: EPI100 group; Drug: Bupivacaine Only; Drug: EPI25

Study type: Interventional

Funder types: Other

Identifiers

NCT02619409

Pro00039232

Details and patient eligibility

About

Bupivacaine spinal is commonly performed as the primary anesthetic for orthopedic procedures. In some cases the duration of the block is inadequate. An epinephrine wash is sometimes performed to prolong the duration of the block. The epinephrine wash may prolong the duration of the block, and if it does, to what extent?

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years of age or older
• Patients scheduled for total hip or knee replacement

Exclusion criteria

• Patients taking anticoagulation
• Infection at or near the intended needle insertion site
• Patients with sacral decubitus ulcer at or near the intended needle insertion site aortic stenosis
• Complex spine anatomy
• ASA class greater than III
• Failed SAB as determined by the staff anesthesiologist

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 5 patient groups, including a placebo group

Bupivacaine Only

Placebo Comparator group

Description:

The bupivacaine only group will receive bupivacaine 0.5% 3cc plus sterile saline 0.1cc.

Treatment:

Drug: Bupivacaine Only

EPI25 group

Active Comparator group

Description:

The EPI25 group will receive bupivacaine 0.5% 3cc, epinephrine 1:1000 0.025cc, and sterile saline 0.075cc.

Treatment:

Drug: EPI25

EPI50 group

Active Comparator group

Description:

The EPI50 group will receive bupivacaine 0.5% 3cc, epinephrine 1:1000 0.05cc, and sterile saline 0.05cc.

Treatment:

Drug: EPI50 group

EPI75 group

Active Comparator group

Description:

The EPI75 group will receive bupivacaine 0.5% 3cc, epinephrine 1:1000 0.075 cc, and sterile saline 0.025%.

Treatment:

Drug: EPI75 group

EPI100 group

Active Comparator group

Description:

The EPI100 group will receive bupivacaine 0.5% 3cc, and epinephrine 1:1000 0.1cc

Treatment:

Drug: EPI100 group