Evaluation of the Effect of Biofiller PRP Application on Knee Osteoarthritis

Necmettin Erbakan University

Status: Not yet enrolling

Conditions: Femoral Cartilage Thickness; Knee Osteoarthritis; Biofiller PRP

Treatments: Other: biofiller prp

Study type: Interventional

Funder types: Other

Identifiers

NCT06946056

Büşra Demirtaş

Details and patient eligibility

About

The aim of this study is to evaluate the effects of biofiller PRP, on pain, range of motion, quality of life, and femoral cartilage thickness in patients with knee osteoarthritis.

Full description

Patients who are admitted and diagnosed with knee osteoarthritis based on anamnesis, physical examination and imaging methods are included in the study

Enrollment: 60 estimated patients

Sex: All

Ages: 45 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1-45-65 years old 2-Diagnosis of knee OA according to ACR clinical and radiological diagnostic criteria 3-Kellgren Lawrence stage II or III 4-Knee pain for at least 6 months 5-Visual analog scale (VAS) score of at least 3 or more

Exclusion criteria

1 - History of surgery or traumatic injury 2-Inflammatory arthritis 3-History of cancer, bleeding diathesis and psychiatric disease 4-Those who have a disease that limits their participation in exercises (severe chronic obstructive lung disease, severe heart failure, history of cerebrovascular events) 5-Hip and ankle problems 6-Participating in another physical therapy program in the last 3 months 7-History of intra-articular injections in the last 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Biofiller platelet rich plasma

Active Comparator group

Description:

Ten ml of the patient's blood wasdrawn in a syringe pre-filled with 1 mLacid citrate dextrose(anticoagulant). It wascentrifuged firstat 4000 rotations per minute (RPM)for 15 min and thenat 1500 RPM for 5 min. The upper part,i.e.,platelet-poor plasma (PPP) was withdrawn in a 5 mL syringe. PRP was incubated in hot incubator at 100a °C for 5 min and then cooled in a refrigerator for 5 min.

Treatment:

Other: biofiller prp

Platelet rich plasma

Active Comparator group

Description:

Ten ml of the patient's blood wasdrawn in a syringe pre-filled with 1 mLacid citrate dextrose(anticoagulant). It wascentrifuged firstat 4000 rotations per minute (RPM)for 15 min and thenat 1500 RPM for 5 min. The upper part,i.e.,platelet-poor plasma (PPP) was withdrawn in a 5 mL syringe

Treatment:

Other: biofiller prp