Evaluation of the Effect of Narrowband UVB Versus Methotrexate on Serum Chitotriosidase Level in Psoriasis

Aswan University Hospital

Status and phase: Active, not recruiting; Phase 4

Conditions: Psoriasis

Treatments: Drug: Methotrexate; Radiation: Narrowband ultraviolet B

Study type: Interventional

Funder types: Other

Identifiers

NCT05427175

593/1/22

Details and patient eligibility

About

The aim of the study is to evaluate the effect of NB-UVB versus MTX on serum Chitotriosidase level in psoriatic patients.

Enrollment: 30 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with moderate to severe plaque psoriasis of any age and gender.

Exclusion criteria

• History of psoriasis treatment with systemic and biological agents prior to the study for at least 3 months.
• Pregnancy and lactation.
• Infections.
• Patients with chronic diseases: hepatic disorders, hematologic diseases, chronic renal failure or cancer.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Narrowband ultraviolet B

Active Comparator group

Description:

Patients will receive 8 sessions of NB-UVB per month for 3 successive months

Treatment:

Radiation: Narrowband ultraviolet B

Methotrexate

Active Comparator group

Description:

Patients will receive 25 mg/1ml of methotrexate vial per week for 3 successive months

Treatment:

Drug: Methotrexate

healthy individuals as control group

No Intervention group