Evaluation of the Effect of Sitagliptin on Gut Microbiota in Patients With Newly Diagnosed Type 2 Diabetes

Soochow University

Status: Unknown

Conditions: Type 2 Diabetes

Treatments: Drug: Sitagliptin

Study type: Interventional

Funder types: Other

Identifiers

NCT02900417

SecondSoochowU

Details and patient eligibility

About

The present study will recruit 9 newly diagnosed type 2 diabetic patient to receive sitagliptin 100mg daily for 12 weeks. The aim of this study was to investigate the composition of gut microbiota before and after the therapy of sitagliptin.

Full description

The present study will included 9 newly diagnosed type 2 diabetic patient to receive sitagliptin 100mg daily for 12 weeks. These patients will receive 75g oral glucose tolerance test and fasting plasma glucose levels, lipids levels, fasting insulin levels and 2 hour post-load plasma glucose levels will be measured. Stool samples will be collected before the initiation of the use of sitagliptin. After 12 weeks, all patients will have fasting plasma glucose levels, lipids levels, fasting insulin levels tested. Stool samples will be collected again.

Enrollment: 9 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newly-diagnosed type 2 diabetic patients aged between 40-70 years

Exclusion criteria

• Any chronic disease (other than diabetes)
• Alcohol consumption/smoking
• Pregnancy/breastfeeding
• The use of antibiotics, pro-prebiotics within 3 months
• History of intestinal surgery

Trial design

9 participants in 1 patient group

sitagliptin

Experimental group

Description:

All the patients will receive sitagliptin 100mg daily.

Treatment:

Drug: Sitagliptin