Evaluation of the Effectiveness of Home-Use Desensitizing Agents on Dentin Hypersensitivity

Çanakkale Onsekiz Mart University

Status: Completed

Conditions: Dentin Sensitivity

Treatments: Other: Casein Phosphopeptide Amorphous Calcium Phosphate; Other: Arginine; Other: Control group; Other: Potassium Nitrate; Other: Novamin; Other: Propolis

Study type: Interventional

Funder types: Other

Identifiers

NCT06216262

TSA-2023-4535

Details and patient eligibility

About

Dentin sensitivity is one of the most common problems in society and affects the quality of life related to oral health. Agents such as toothpaste, mouthwash, and dental cream are home-type desensitizing agents used as the first step in the treatment of dentin hypersensitivity. A total of 180 individuals with dentin sensitivity will be included in the study and the individuals will be randomly divided into 6 groups. Individuals in the 1st Group will be given arginine-containing toothpaste, individuals in the 2nd Group will be given novamin-containing toothpaste, individuals in the 3rd Group will be given propolis-containing toothpaste, individuals in the 4th Group will be given casein phosphopeptide amorphous calcium phosphate-containing dental cream, and individuals in the 5th Group will be given mouthwash containing potassium nitrate. Classic toothpaste with 1450 ppm fluoride will be distributed to individuals in the control group, which is the 6th group. The Dentin Hypersensitivity Experience Questionnaire (DHEQ-15), consisting of 15 questions, will be used to evaluate dentin sensitivity. Visual Analogue Scale (VAS) will be used to determine the individual's pain score in dentin sensitivity, and the individual will be asked to score the intensity of pain experienced between 0-10 points. Finally, in the evaluation of dentin sensitivity, a single dentist will apply air to the cervix of the tooth from a distance of 1 cm for 1 second, and the Schiff Sensitivity Scale score will be determined through clinical examination. A score between 0 and 3 will be determined by the dentist according to the patient's response to the air stimulus. The effectiveness of the home-use desensitizing agents used in the treatment of dentin hypersensitivity was evaluated with DHEQ-15, VAS and Schiff Sensitivity Scale; Baseline, 4th and 8th week scores will be compared.

Enrollment: 180 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between 18-70 years old
• General health condition is good
• Individuals with sensitivity in 2 or more non-adjacent teeth

Exclusion criteria

• Pregnant or breastfeeding women
• Advanced periodontal diseases
• Chronic diseases that may affect the study results
• Major oral pathologies
• Use of anticonvulsant, antihistamine, antidepressant, sedative, tranquilizer medication
• Use of desensitizing paste in the last 3 months
• Individuals who have been treated for periodontal disease in the last 12 months

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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180 participants in 6 patient groups

Control group

Active Comparator group

Description:

1450 ppm fluoride toothpaste

Treatment:

Other: Control group

Arginine

Active Comparator group

Description:

toothpaste containing arginine

Treatment:

Other: Arginine

Novamin

Active Comparator group

Description:

toothpaste containing novamin

Treatment:

Other: Novamin

Propolis

Active Comparator group

Description:

toothpaste containing propolis

Treatment:

Other: Propolis

Casein Phosphopeptide Amorphous Calcium Phosphate

Active Comparator group

Description:

Dental cream containing casein phosphopeptide amorphous calcium phosphate

Treatment:

Other: Control group

Other: Casein Phosphopeptide Amorphous Calcium Phosphate

Potassium Nitrate

Active Comparator group

Description:

mouthwash containing potassium nitrate

Treatment:

Other: Potassium Nitrate

Other: Control group