Evaluation of the Effects of A-Prf and Oral Dexamethasone Use in Third Molar Extraction

Yuzuncu Yıl University

Status: Completed

Conditions: Wisdom Tooth Removal

Treatments: Procedure: Impacted lower wisdom tooth extraction

Study type: Interventional

Funder types: Other

Identifiers

NCT06823934

YYU-13/20.09.2021

Details and patient eligibility

About

Impacted third molar tooth extraction is one of the most frequently performed procedures in oral surgery. Complications such as pain, swelling and trismus, which are frequently seen after this operation, affect the patient's quality of life in the postoperative period. Today, there are many methods used to prevent or treat these complications. Corticosteroid use and A-PRF biomaterial obtained from the patient's own blood are some of these methods. In patients with bilaterally impacted lower wisdom teeth, A-PRF was applied to one side after extraction and postoperative oral dexamethasone was used to the other side. Intra-group and inter-group evaluations were made by collecting the patients' pain, edema, trismus and analgesic use data.

Full description

Impacted third molar tooth extraction is one of the most commonly performed procedures in oral surgery. Complications such as pain, swelling and trismus, which are frequently seen after this operation, affect the quality of life of the patient in the postoperative period and may cause patients to avoid this procedure. Today, there are many methods used to prevent or treat these complications. The use of corticosteroids and the A-PRF biomaterial obtained from the patient's own blood are some of these methods. No study has been found in the literature comparing the effects of oral use of dexamethasone, a corticosteroid drug, with A-PRF on pain, edema, trismus and analgesic use. In patients with bilateral impacted lower wisdom teeth, A-PRF was applied to the extraction site after extraction on one side and postoperative oral dexamethasone was used on the other side. Pain, edema, trismus and analgesic use data of the patients were collected and in-group and intergroup evaluations were made.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Not having any systemic disease,
• Being over 18 years of age,
• Bilateral teeth being in similar positions and being completely impacted,
• Not having any allergies to the drugs to be used in the study.

Exclusion criteria

• Infection in the area where the extraction will be performed,
• Pregnancy or breastfeeding,
• Using medication up to 2 weeks before tooth extraction,
• Not using prescribed medications regularly,
• Not coming to regular check-ups.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Oral Dexamethasone

Active Comparator group

Description:

After the extraction of the impacted wisdom tooth, the patient was prescribed oral dexamethasone (Dekort 4mg tablet, S:3\*1 DEVA brand) for 3 days.

Treatment:

Procedure: Impacted lower wisdom tooth extraction

A-Prf

Active Comparator group

Description:

A-PRF was placed in the patients' tooth extraction sockets and the flap was closed primarily using 3/0 silk sutures.

Treatment:

Procedure: Impacted lower wisdom tooth extraction