Evaluation of the Effects of Pre-operative Deflazacort on Post-operative Pain, Edema and Trismus

Yuzuncu Yıl University

Status and phase: Active, not recruiting; Phase 4

Conditions: Impacted Third Molar Tooth

Treatments: Drug: Sugar pill; Drug: Deflazacort 30 MG Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT04365088

19.07.2017/06

Details and patient eligibility

About

Removal of impacted lower third molar teeth is one of the most common oral surgical procedures, and these operations often lead to various complications in patients. Antibiotics, analgesics and/or anti-inflammatory drugs are prescribed for the treatment of complications encountered. Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system to block pain signaling to the brain. Based on this information, in this study, it is aimed to evaluate the effects of deflazacort preoperatively on the postoperative pain, swelling and trismus.

Enrollment: 35 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• absence of any systemic disease,
• having bilateral impacted mandibular third molar teeth in a similar position
• absence of allergy to any of the drugs used in the study,
• absence of pregnancy/lactating state,
• no history of any medication use during at least 2 week before the operation.

Exclusion criteria

• not regularly coming to the controls,
• not using their medicines regularly,
• using any additional medication that may affect the outcome of the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Quadruple Blind

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35 participants in 2 patient groups, including a placebo group

Deflazacort

Experimental group

Description:

Deflazacort is a glucocorticoid used as an anti-inflammatory drug. We used deflazacort 30 mg tablet. Patient took a pill once preoperatively (1 hour ago) in third molar surgery.

Treatment:

Drug: Deflazacort 30 MG Oral Tablet

Sugar pill

Placebo Comparator group

Description:

Placebo is an inert substance or treatment which is designed to have no therapeutic value. Patients took sugar pill for plasebo once one hour before operation.

Treatment:

Drug: Sugar pill