Evaluation of the Efficacy and Safety of Oxacom® in Patients With Pulmonary Arterial Hypertension

National Medical Research Center for Cardiology, Ministry of Health of Russian Federation

Status and phase: Enrolling; Phase 3; Phase 2

Conditions: Pulmonary Arterial Hypertension

Treatments: Drug: Placebo; Drug: Oxacom

Study type: Interventional

Funder types: Other

Identifiers

NCT06683040

ОКСА-ЛАГ-1 (Other Identifier)

OXA-PAH-1

Details and patient eligibility

About

A multicenter, randomized, double-blind, placebo-controlled, phase II-III clinical trial to evaluate the efficacy and safety of the study drug in adult patients with pulmonary arterial hypertension (PAH).

The trial will evaluate the efficacy and safety of both single and multi-dose (seven-day) administrations of the study drug in three dosages: 0.03 mg/kg, 0.10 mg/kg, and 0.17 mg/kg.

The trial is an observer-blinded trial, since the appearance of the study drug and Placebo differs from each other. Patients included in the trial, as well as trial coordinators, investigators, and study center staff will be blinded. The only unblinded staff in the study centers will be those who preparing IP/Placebo and administering IP/Placebo to the study patients.

The trial will include 200 patients with PAH, who will be sequentially included in the trial in two stages.

Enrollment: 260 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed diagnosis of PAH II or III functional class according to WHO classification
• Symptomatic PAH group 1 according to clinical classification
• Patients who have not previously received any PAH-specific therapy OR patients who have received endothelin receptor antagonists and/or iloprost/selexipag at stable doses for at least 3 months prior to the initial right heart catheterization.
• Ability to perform reproducible 6-min walking test at the screening with a distance from 150 to 450 m.

Exclusion criteria

• as per the study protocol

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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260 participants in 4 patient groups, including a placebo group

0.030 mg\kg

Experimental group

Treatment:

Drug: Oxacom

0.100 mg\kg

Experimental group

Treatment:

Drug: Oxacom

0.170 mg\kg

Experimental group

Treatment:

Drug: Oxacom

Placebo

Placebo Comparator group

Treatment:

Drug: Placebo