Evaluation of the Efficacy and Safety of Pazopanib in Combination with TGI/CIV for Recurrent or Refractory Rhabdomyosarcoma in Children or Adolescents

Shandong First Medical University

Status and phase: Enrolling; Phase 2

Conditions: Rhabdomyosarcoma, Recurrent, Refractory

Treatments: Drug: TGI chemotherapy; Drug: CIV chemotherapy; Drug: pazopanib

Study type: Interventional

Funder types: Other

Identifiers

NCT06816771

SDZLEC2024-413-02

Details and patient eligibility

About

To evaluate the efficacy and safety of pazopanib combined with TGI/CIV chemotherapy in children and adolescents with recurrent or refractory rhabdomyosarcoma.

Enrollment: 38 estimated patients

Sex: All

Ages: 2 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

1. Histologically or cytologically confirmed rhabdomyosarcoma (RMS).

2. Patients diagnosed with recurrent/refractory RMS based on clinical diagnostic criteria. Recurrence is defined as disease recurrence confirmed after achieving complete remission and completing at least one line of standard treatment; refractory is defined as disease progression as per the Response Evaluation Criteria in Solid Tumors (RECIST 1.1) after at least four cycles of first-line chemotherapy.

   First-line standard treatment can refer to the "Diagnosis and Treatment Guidelines for Rhabdomyosarcoma in Children and Adolescents (2019 Edition)".

3. Patients must have measurable lesions as per RECIST 1.1 criteria.

4. Age ≥ 2 years and ≤ 18 years, with no gender restrictions.

5. Karnofsky Performance Scale (KPS) score of 70-100% (> 12 years) or Lansky Performance Scale score of 70-100% (≤ 12 years).

6. Expected survival time ≥ 12 weeks.

7. Before initiating any project-related procedures, the parents/guardians of the child or adolescent subjects must be able to understand, consent, and sign the informed consent form (ICF) and applicable assent form; the subjects must be able to express consent with the consent of their parents/guardians (if applicable).

8. Adequate organ and bone marrow function, defined as follows:

Bone marrow function:

1. Absolute neutrophil count (ANC) ≥ 1.5×109/L (≥ 0.5×109/L if bone marrow metastasis)
2. Platelet count ≥ 100×109/L (≥ 75×109/L if bone marrow metastasis) Hb ≥ 65 g/L (blood transfusion is allowed)
3. Hematopoietic growth factors: Treatment should be initiated at least 14 days after the last administration of long-acting growth factors or 1 day after the last administration of short-acting growth factors. renal function

1. Serum creatinine ≤ 1.5 times the upper limit of normal (ULN) 2) If serum creatinine > 1.5 ULN, creatinine clearance rate > 70 ml/min/1.73 m² Liver function

1. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN (≤ 5 × ULN for patients with liver metastasis)
2. Total bilirubin ≤ 1.5 times ULN Cardiac function

1. Echocardiography LVEF ≥ 50%; 2) No severe cardiac rhythm or conduction abnormalities on electrocardiogram.

Exclusion criteria:

1. Received any of the following treatments within 2 weeks before treatment: radiotherapy, chemotherapy, or molecular targeted therapy for tumors; other investigational drugs; or live attenuated vaccines.
2. Patients who have received anti-angiogenic targeted drugs such as apatinib, pazopanib, sunitinib, sorafenib, bevacizumab, imatinib, crizotinib, famitinib, anlotinib, regorafenib, endostatin, etc. within the past 3 months.
3. Central nervous system metastasis.
4. A history of thrombosis within 3 months before enrollment and anticoagulation treatment for less than 6 weeks.
5. Known bleeding tendency, significant clinical bleeding symptoms within 3 months before treatment or definite bleeding tendency, such as gastrointestinal bleeding, hemorrhagic gastric ulcer, baseline fecal occult blood ++ or above, vasculitis, etc.; or thrombotic events within 6 months before treatment, such as cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage, cerebral infarction), deep vein thrombosis and pulmonary embolism, etc.; or need long-term anticoagulation treatment with warfarin or heparin, or need long-term antiplatelet treatment (aspirin ≥ 300 mg/day or clopidogrel ≥ 75 mg/day).
6. Uncontrolled hypertension and proteinuria in the recent period. And cannot be well controlled by antihypertensive drugs (infants > 100/60 mmHg, preschool children (< 6 years old) > 110/70 mmHg, school-age children (6-12 years old) > 120/80 mmHg, adolescents and adults > 140/90 mmHg).
7. Use of antiepileptic drugs.
8. Long-term unhealed wounds, ulcers or fractures, major surgery within 28 days before enrollment or minor surgery within 7 days, abdominal fistula, gastrointestinal perforation.
9. Uncontrolled severe infection.
10. The presence of active heart disease within 6 months before treatment, including myocardial infarction, severe/unstable angina, etc. Poorly controlled arrhythmias with left ventricular ejection fraction < 50% on echocardiography (including QTcF intervals >450 ms in men and >470 ms in women).
11. Any other malignancy was diagnosed within 3 years before treatment.
12. Known allergy to the study drug or any of its excipient.
13. Human immunodeficiency virus (HIV) infection, active hepatitis B (hepatitis B surface antigen positive and HBV DNA ≥ 500 IU/ml), hepatitis C (hepatitis C antibody positive and HCV-RNA above the detection limit of the assay).
14. According to the judgment of the researchers, patients with large tumors, easy to rupture and bleeding, and bleeding caused by tumor retraction are at high risk.
15. Concomitant medical conditions (e.g., poorly controlled hypertension, severe diabetes, neurological or psychiatric conditions, etc.) or any other condition that, in the investigator's judgment, could seriously endanger the safety of the subject, confound the study results, or interfere with the completion of the study.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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38 participants in 1 patient group

Experimental group

Experimental group

Description:

The participant take pazopanib once daily orally in combination with a total of 2 cycles(6 weeks) of TGI chemotherapy(nab⁃Paclitaxel+ gemcitabine + ifosfamide)/CIV(cyclophosphamide +Irinotecan + vinorelbine).Each cycle of TGI/CIV chemotherapy will last for 3 weeks, TGI will be given in cycle 1 and CIV will be given cycle 2 . At week 6, the participant will have scans and tests to reevaluate the tumor's response to the treatment. The participant will receive an additional 6 weeks (2 cycles) of the same chemotherapy in the absence of disease progression or unacceptable toxicity. After 4 cycles of chemotherapy, The investigator will re-evaluate the tumor again at week 12 and the patient will undergo other treatments(chemotherapy, radiation, surgery, etc.), but will be closely watched for any signs of tumor recurrence or progression.

Treatment:

Drug: pazopanib

Drug: CIV chemotherapy

Drug: TGI chemotherapy