Evaluation of the Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5 - Fluorouracil in Treatment of Plantar Warts

Sohag University

Status: Enrolling

Conditions: Plantar Wart

Treatments: Drug: 5 fluorouracil; Drug: combined digoxin and furosemide

Study type: Interventional

Funder types: Other

Identifiers

NCT05520658

Soh-Med-22-07-01

Details and patient eligibility

About

Warts are common skin infections caused by human papillomavirus (HPV), which can cause a variety of skin presentations according to its type, site and the immune status .Nongenital warts may be presented as common, plane, plantar, filiform, or mucosal warts .Most people are affected by cutaneous warts, either plantar warts or common warts .prevalence of skin warts is between 3% and 13% and plantar warts are about 30% of skin warts in western world .Majority of cases occur in adolescent and young adults

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age:>18 years .
• Sex: both males and females will be included.
• Confirmed diagnosis by clinical and dermoscopic examination of plantar warts will be made

Exclusion criteria

• Patients with history or evidenced hypersensitivity to any component used in this study.
• Pregnancy & lactating.
• Patients who receive immune suppressive therapy.
• Patients who receive any wart treatment during the last 2 months before enrollment in the study.
• Patients with systemic illness especially cardiac patients.
• Patients who refused participation in the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

group A

Active Comparator group

Description:

patients will receive intralesional combined digoxin and furosemide , one session every 2 weeks for maximum 6 sessions

Treatment:

Drug: combined digoxin and furosemide

group B

Active Comparator group

Description:

patients will receive intralesional 5 fluorouracil mixed with 1ml of 2% lignocaine and epinephrine one session every 2 weeks for maximum 6 sessions .

Treatment:

Drug: 5 fluorouracil