Evaluation of the Efficacy of Ponatinib in Ph+ ALL in the Real-world (PONA4ALL Ph+)

Gruppo Italiano Malattie EMatologiche dell'Adulto

Status: Begins enrollment in 1 month

Conditions: Acute Lymphobkastic Leukemia; Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Study type: Observational

Funder types: Other

Identifiers

NCT07356960

ALL3125

Details and patient eligibility

About

The goal of this retrospective observational study is to learn about the efficacy of ponatinib in Philadelphia-positive ALL (Ph+ ALL) patients in a real-world setting. The main goal of the study is to assess the rate of complete molecular response (CMR) induced by ponatinib in patients treated under the regulations of Law 648/96, outside clinical trials.

Patients who were treated with ponatinib as part of their regular medical care and completed the follow-up period will be included in the study.

Full description

This is a non-interventional, multicenter, strictly retrospective study including Ph+ ALL patients treated with ponatinib, alone or in combination with other antileukaemic agents, under Law 648/96. According to AIFA guideline 425-2024, all patients who received ponatinib as first-line treatment under Law 648/96 are eligible for inclusion provided that, at the time of enrolment, they are alive and have at least 18 months of retrospective observation available from the start of ponatinib treatment, or have died/lost to follow-up at any time after treatment initiation, regardless of the length of available follow-up.

Enrollment: 103 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patient is > 18 years old;

2. Patient was treated in first-line with ponatinib monotherapy or in association with chemotherapy or immunotherapy;

3. Patient received ponatinib under the regulations of Law 648/96;

4. - Patient is alive and have at least 18 months of retrospective observation available from the start of ponatinib treatment, OR

   - has died/lost to follow-up at any time after treatment initiation, regardless of the length of available follow-up;

5. Signed informed consent, if applicable.

Exclusion criteria

• None

Trial design

103 participants in 1 patient group

Patients treated with ponatinib in first line

Description:

Patients treated with ponatinib as first line, alone or in combination with other antileukaemic agents, under Law 648/96.