Evaluation of the Elasticity of the Mitral Valve

Centre Hospitalier Universitaire de Saint Etienne

Status: Enrolling

Conditions: Mitral Valve Disease

Treatments: Other: Data collection on patient history and intraoperative results.

Study type: Observational

Funder types: Other

Identifiers

NCT06153563

IRBN1102022/CHUSTE

Details and patient eligibility

About

There is no information in the literature on the mechanobiological characteristics of mitral valve chords in living humans. All examinations were carried out on tissues taken from animals, either from cadavers or from frozen human tissues. The objective is to determine mechanobiological and histological characteristics of the mitral valve chords in living humans, as well as to compare differences in elasticity in different groups (Group A: patients with mitral valve prolapse versus Group B: patients with restrictive ischemic mitral valve).

Full description

The prospective study will be conducted on 20 patients, who will be selected consecutively without randomization. The inclusion and exclusion criteria are determined.

The harvested tissue will not be frozen and will kept in natural conditions as close as possible.

Enrollment: 30 estimated patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

All patients programmed for mitral valve replacement who have more than 45 years old

Exclusion criteria

• Patients with mitral calcification
• Mitral valve rheumatic disease
• Mitral valve infections
• Redo surgery on the mitral valve

Trial design

30 participants in 2 patient groups

Mitral valve prolapse

Description:

Patients with mitral valve prolapse

Treatment:

Other: Data collection on patient history and intraoperative results.

Restrictive ischemic mitral valve

Description:

Patients with restrictive ischemic mitral valve

Treatment:

Other: Data collection on patient history and intraoperative results.